Study On The Relationship Between Coronary Artery Disease And CAR,WMR And DNLR In Patients With Coronary Heart Disease

Objective:C-reactive protein(CRP),albumin(ALB),white blood cell count(WBC),mean platelet volume ratio(MPV),and neutrophil count(NEU)were measured.Calculation of c-reactive protein and albumin ratio(CAR),white blood cell count and mean platelet volume(WMR),neutrophil counts/(white blood cell count,neutrophils count)(dNLR),understand its change in different levels in patients with coronary artery disease,analysis the CAR,WMR,dNLR correlation and predictive value in patients with coronary heart disease(CHD).Methods:A total of 192 patients who initial underwent coronary angiography and were hospitalized in the Department of Cardiology,Affiliated Hospital of Qinghai University from October 2019 to November 2021 were enrolled in this study.According to the clinical diagnostic guidelines of coronary heart disease(CHD)issued by the International Society of Cardiology in 1979,if the stenosis diameter≥50%,CHD was diagnosed.According to the results,147 patients were diagnosed with CHD.There were 47 cases in the single-vessel disease group,44 cases in the double-vessel disease group,and 56 cases in the three-vessel disease group.The GENSINI score of each coronary heart disease patient was calculated,and 45 cases of CAG negative in the same period were the control group.For each patient included in the study,fasting blood was collected in the morning for CRP,ALB,NEU and MPV,and the results were calculated by statistical software.Results:1.Compared with the control group,there was no significant difference in age,gender,Uric acid(UA)and other general information between the two groups(P>0.05);The levels of CAR,WMR and dNLR in CHD group were higher than those in control group,and the differences were statistically significant(P<0.05);2.There were statistically significant differences in CAR,WMR and dNLR levels in CHD subgroups(P<0.05);There was no significant difference in age,UA and other general data between subgroups(P>0.05);There were significant differences in CAR,WMR and dNLR levels between the single-vessel group and the two-vessel group(P<0.05);CAR,WMR and dNLR levels were significantly different between the single-vessel group and the three-vessel group(P<0.05);There were statistically significant differences in CAR,WMR and dNLR levels between the two-vessel group and the three-vessel group(P<0.05).3.Correlation analysis:CAR(r _S=0.600,P<0.05),WMR(r _S=0.463,P<0.05),dNLR(r _S=0.620,P<0.05)was positively correlated with Gensini score;CAR(r _S=0.647,P<0.05),WMR(r _S=0.423,P<0.05),dNLR(r _S=0.576,P<0.05)was positively correlated with Gensini score level.4.When evaluating the diagnostic value of CAR,WMR and dNLR for CHD by ROC curve,it was found that the area under the CAR curve was 0.81.When CAR=0.12,the diagnostic efficiency was the highest,with a sensitivity of 0.74 and specificity of 0.84.The area under the WMR curve was 0.75,and the sensitivity and specificity were 0.66 and 0.84 when WMR=0.61.The area under the dNLR curve was0.82.When dNLR=2.27,the diagnostic efficiency was the highest,with a sensitivity of 0.65 and specificity of 0.87.Conclusions:1.The levels of CAR,WMR and dNLR in CHD patients increased with the number of coronary artery lesions and Gensini score,showing a positive correlation.The levels of the three can reflect the status and severity of coronary artery.2.When patients with coronary artery disease CAR>0.12 WMR>0.61 dNLR>2.27,coronary artery lesions are more likely to occur,which has certain clinical value in assessing the severity of coronary heart disease.