Clinical Effect Of Nalbuphine For Patients With Artificial Abortion And Hysteroscopy

Part One Clinical Effect of Nalbuphine combined with Propofol for Patients with Artificial AbortionObjective:To evaluate the clinical effect of nalbuphine combined with propofol for patients with artificial abortion.Methods:100 patients with intrauterine pregnancy undergoing artificial abortion were divided into 2 groups:propofol group?group P?and nalbuphine combined with propofol group?group PN?using a random number table.All patients intramuscularly injected phloroglucinol 40mg.Before the operation,propofol 2.0mg/kg was intravenously injected to the patients in group P.In group PN,nalbuphine 0.1mg/kg was intravenously injected to the patients 2minutes before propofol 2.0 mg/kg was injected.Propofol 0.5mg/kg was injected when the patients developed limbs activities during the operation.The changes of MAP,HR,and SpO₂ in the two groups in T₀,T₁,T₂ and T₃ were recorded.The total amount of propofol,operation time,recovery time,VAS score in 5 minutes after recovery and the highest VAS score in PACU,the adverse effects such as dizziness,nausea,vomiting and respiratory depression and the surgeon's and patients'satisfaction with the anesthetic effect were also recorded in the two groups.Results:There were no statistically significant differences in age,height,weight,and the history of vaginal delivery between two groups?P>0.05?.There were also no statistically significant differences in operation time and recovery time between two groups?P>0.05?.Compared with group P,there were no statistically significant differences in MAP?HR?SpO₂ in group PN?P>0.05?.Compared with group P,the total amount of propofol and VAS score were decreased in group PN?P<0.05?,and the surgeon's and patients'satisfaction with the anesthetic effect were also higher?P<0.05?.Summary:0.1mg/kg nalbuphine combined with propofol using for patients with artificial abortion is safe and effective.During the operation,the patients'body movement reaction is less and the operation process is stable.After operation,the recovery time is not delayed.Meanwhile,the surgeon's and patients'satisfaction with the anesthetic effect are higher and it also significantly alleviates the pain of uterine contraction after operation.Part Two Comparison of Nalbuphine and Oxycodone Combined with Propofol on Clinical Effect for Patients with HysteroscopyObjective:To compare the clinical effect of nalbuphine and oxycodone combined with propofol for patients with hysteroscopy.Methods:150 patients with submucosal myoma and endometrial polyp undergoing hysteroscopy were divided into 3 groups:propofol group?group P?,nalbuphine combined with propofol group?group PN?and oxycodone combined with propofol group?group PQ?using a random number table.Before the operation,all patients intravenously injected phloroglucinol 80mg.After 3 minutes,propofol 1.5mg/kg was intravenously injected to the patients in group P.In group PN and group PQ,nalbuphine 0.1mg/kg and oxycodone0.05mg/kg were intravenously injected to the patients,and after 2 minutes,propofol 1.5mg/kg was injected.Propofol 0.5mg/kg was injected when the patients developed limbs activities during the operation.The changes of MAP,HR,and SpO₂ in three groups in T₀,T₁,T₂ and T₃ were recorded.The limbs activities at the beginning of the operation,the total amount of propofol,operation time,recovery time,VAS score in 10 minutes after the operation,the proportion of VAS score more than 4,the surgeon's satisfaction and the adverse effects such as dizziness,nausea,vomiting and respiratory depression were also recorded in three groups.Results:There were no statistically significant differences in age,height and weight among three groups?P>0.05?.Compared with group P,there were no statistically significant difference in MAP?HR?SpO₂ of T_0-3-3 in group PN and in group PQ?P>0.05?.Compared with T₀,MAP was decreased in T₁ in three groups?P<0.05?.Compared with group P,the total amount of propofol,recovery time,VAS score in 10 minutes after the operation and the proportion of VAS score more than 4 were decreased in group PN and group PQ?P<0.05?,and the surgeon's satisfaction with the anesthetic effect was increased?P<0.05?.Compared with group P,the limbs activities at the beginning of the operation were decreased in group PN?P<0.05?.And the VAS score in 10minutes after the operation was lower in group PN than in group PQ?P<0.05?.Summary:0.1mg/kg nalbuphine or 0.05mg/kg oxycodone combined with propofol for patients with hysteroscopy is safe and effective.Compared with propofol alone,the operation process is more stable and the surgeon's satisfaction with the anesthetic effect is higher.Compared with 0.05mg/kg oxycodone,0.1mg/kg nalbuphine is more effective.Conclusions:1.0.1mg/kg nalbuphine for patients with artificial abortion or hysteroscopy is safe and effective.During the operation,the patients'body movement reaction is less and the operation process is stable.After operation,the recovery time is not delayed and the adverse effects are decreased.Meanwhile,the surgeon's and patients'satisfaction with the anesthetic effect are higher.2.Compared with 0.05mg/kg oxycodone,0.1mg/kg nalbuphine is more effective to alleviate the pain of uterine contraction after hysteroscopy.