Comparison Of Early Analgesic Effects Of Different Opioid Analgesics For Patients Undergoing Laparoscopic Cholecystectomy After Induction Of General Anesthesia

Objective: Comparison of the equivalent analgesic effects of oxycodone,nalbuphine,and sufentanil used in laparoscopic cholecystectomy patients in the induction of general anesthesia in the early postoperative period.Methods: Ninety patients aged 18-65 years old with ASA grade???were selected from September 2017 to September 2019 in elective laparoscopic cholecystectomy at Shengjing Hospital affiliated to China Medical University.Random number table method was used to divide the patients into three groups: group O(oxycodone group),group N(nabuphine group)and group S(sufentanil group),with 30 cases in each group.During anesthesia induction,atropine 0.01 mg/kg,propofol 2.0 mg/ kg,cis-atracurium 0.15 mg / kg,group O intravenously oxycodone 0.3 mg / kg,group N intravenously nalbuphine 0.3mg/kg,Sufentanil was given intravenously 0.3?g/kg in group S.Anesthesia maintenance was performed by combined inhalation of sevoflurane,nitrous oxide plus remifentanil.After operation,0.375%ropivacaine injection was used for local block at the laparoscopic incision.The visual analog score VAS,comfort score BCS,recovery time of spontaneous breathing,recovery time,and incidence of adverse reactions of patients at 5 minutes,15 minutes,30 minutes,2 hours,4 hours,and 6 hours were recorded.Results: In terms of postoperative analgesia,compared with the S group,the VAS scores at various time points in the O and N groups were significantly decreased(P<0.05),and there was no statistical difference between the O and N groups at each time point(P>0.05).In terms of postoperative patient comfort,there was no statistical difference in BCS within 30 minutes after operation in the three groups(P>0.05).Compared with the S group,the BCS scores in the O and N groups were significantly increased from 30 minutes to 6 hours(P<0.05).There was no significant difference in BCS scores between 30 minutes and 6 hours after operation in groups O and N(P>0.05).In terms of postoperative wake quality,there was no significant difference in spontaneous breathing recovery time among the three groups(P>0.05).Compared with group S,the wake-up time in group O was significantly longer(P<0.05),and there was no statistical difference in wake-up time between group O and N(P>0.05).There was no statistical difference in the incidence of postoperative adverse reactions among the three groups(P>0.05).Conclusion: Oxycodone and nalbuphine can effectively relieve early visceral pain after LC.Compared with the equivalent dose of sufentanil,it can provide effective postoperative analgesia,improve patient comfort,and will not increase adverse reactions.