The Status Quo And Influencing Factors Of Mild Cognitive Impairment In Retired Nurses

Objective:1.To investigate the prevalence of mild cognitive impairment in retired nurses in a top three hospitals;2.To analyze the influencing factors associated with mild cognitive impairment;3.Further analyze the relationship between chronic sleep deprivation and cognitive function domains.Methods:We choose nurses who retired between January 1,1987 and June 31,2017 in a top three hospital as our subjects.Inclusion criteria: 1.age 55-85 years;2.long-term residence in the city(residence time ? 20 years);3.can cooperate with the completion of questionnaires and cognitive assessment.Those who met the inclusion criteria were screened by the ADL score and the Hamilton Depression Scale(HAMD).Those whose ADL was rated at 0 and the HAMD was < 7(to rule out suspicious cognitive impairment due to depression)conduct general data collection and cognitive assessment;organize questionnaire data,count the total scores of each subject and scores;make final diagnosis according to the latest diagnostic criteria of MCI;analyze the prevalence and influencing factors of MCI;The retired nurses were divided into sleep deprivation group and non-sleep deprivation group according to whether sleep deprivation existed.The total scores and each fraction of the cognitive scale were compared to analyze the relationship between chronic sleep deprivation state and cognitive function domains.Results:There were 117 retired nurses who met the requirements,117 questionnaires were distributed,and 106 valid questionnaires were collected.The investigation rate was90.5%;among them,85 were MCI patients,and the prevalence rate was 79.3%.There were statistically significant differences between the MCI group and the normal group in terms of age,education level,total night shift years,monthly night shift days,and sleep duration after night shift(P < 0.05);Among them,total night shift years(OR = 2.577,95%CI(1.302,5.100)and monthly night shift days(OR = 2.774,95%CI(1.272,6.049)were independent factors influencing the occurrence of MCI in retired nurses(P < 0.05);There were no statistically significant differences between the MCI group and the normal group in BMI,marital status,residence,total working years,age at night shift,sleep duration at night shift,hypertension,cardiovascular and cerebrovascular disease,diabetes,hyperlipidemia,headache history,diet and exercise habits(P > 0.05).The total scores of MMSE,orientation,immediate memory,attention and calculation ability,delayed recall ability and executive command in the sleep deprivation group were all lower than those in the non-sleep deprivation group,and the differences were statistically significant(P < 0.05).There was no significant difference in the scores of naming ability,retelling ability,reading ability,writing ability and structure imitation between the sleep deprivation group and the non-sleep deprivation group(P > 0.05).The total scores of MoCA total,visual space and executive ability,immediate recall,abstract summarization,delayed recall and orientation were lower in the sleep deprivation group than in the non-sleep deprivation group,the difference was statistically significant(P < 0.05);There was no significant difference in the scores of naming ability,attention and language fluency were not significantly different from those of non-sleep deprivation group(P > 0.05).Conclusion:1.Mild cognitive impairment has a high prevalence in sleep deprived population;2.Influential factors of mild cognitive impairment include age,education level,total night shift years,monthly night shift days,and restorative sleep duration after night shift.The total night shift years and monthly night shift days are independent factors;3.Chronic sleep deprivation affects cognitive function-related cognitive domains,including orientation,immediate memory,attention and computational power,delayed recall,visual space,and execution.Command,abstract summarization ability.