Clinical Observation On Treating Different Syndrome Types Of DPN With QiangHuo Exterior Washing

ObstractiveThis study was to investigate the treatment of different types of diabetic peripheral neuropathy(DPN)patients with different syndromes by observation of the treatment of traditional Chinese medicine syndrome scores and Toronto Clinical Score System(TCSS).The differences between the two aspects,to explore the best indications for the treatment of DPN with Qihuo Exterior Washing,provide an objective basis for the clinical dialectical use of phlegm and external washing to treat DPN.MethodThe patients with DPN who met the inclusion criteria in the Department of Endocrinology and Inpatient Department of Guangzhou Chinese Medicine Hospital were divided into the Qi Deficiency and Blood Stasis Syndrome,the Yang Deficiency Blood Stasis Syndrome,and the Phlegm according to the Guidelines for Clinical Diagnosis and Treatment of Diabetic Peripheral Neuropathy(Chinese Society of Traditional Chinese Medicine,2016).There were 60 cases of Phlegm and Blood Stasis Syndrome,a total of 180 cases.Each type of syndrome was randomly divided into treatment group(QiHuo Exteior Washing+Ipastain)and control group(warm water washing+ipastatin tablets).The treatment period is 4 weeks,during which the original basic treatment is maintained:diet plus exercise control,hypoglycemic regimen and all drugs that affect the results of the study,including Chinese medicine preparations,are discontinued.The changes of TCM syndrome scores and TCSS scores before and after treatment were observed in three groups of patients with different syndrome types.Result1.Compared with before treatment,the TCM syndrome scores of the two groups were significantly improved(P<0.01),and the improvement of syndrome scores was more significant in the treatment group than in the control group(P<0.01).The TCM syndrome scores of the three groups of different syndrome types were significantly improved(P<0.01),and the TCM syndrome scores after treatment,the patients with Yang Deficiency and Blood Stasis type were longer than Qi Deficiency and Blood Stasis type and the Phlegm-Blocking type(P<0.05,P<0.05).There was no significant difference between the Qi Deficiency and Blood Stasis type and the Phlegm-Blocking type(P>0.05).2.The comparison of the improvement of TCM syndromes after treatment,the effective rate was 83.9%in the total treatment group and 62.4%in the control group.The treatment group was superior to the control group(P<0.05).The effective rate of the three groups of different syndrome types were compared with that of the treatment group.The effective rate of Yang Deficiency and Blood Stasis Group was 93.5%,the effective rate of Phlegm and Blood Stasis group was 83.9%,and the effective rate of Qi Deficiency and Blood Stasis group was 74.2%.After the comparison between the two groups,the Yang Deficiency and Blood Stasis group was superior to the Phlegm and Blood Stasis group and the Qi Deficiency and Blood Stasis group(P<0.05,P<0.05).There was no difference between the Phlegm and Blood Stasis group and the Qi Deficiency and Blood Stasis(P>0.05).3.Compared with before treatment,the TCSS Scores of the two groups were significantly lower(P<0.01),and the treatment group was superior to the control group after treatment(P<0.01).The TCSS Scores of the three groups of different syndrome types were significantly lower than those before treatment(P<0.01).The TCSS scores of the syndromes before treatment were different(P<0.05),so the third treatment The TCSS Scores between the group types are not comparable after treament.Compared with the difference of TCSS Scores before and after treatment,The TCSS Scores in the Yang Deficiency and Blood Stasis group were better than those in the Phlegm and Blood Stasis group and the Qi Deficiency and Blood Stasis group(P<0.05,P<0.05),There was no significant difference in the improvement of TCSS Scores between the Phlegm and Blood Stasis group and the Qi Deficiency and Blood Stasis(P>0.05).4.In terms of efficacy evaluation,the effective rate of the total treatment group was 84.9%,and the effective rate of the control group was 60.1%.The treatment group was superior to the control group(P<0.05);the three groups of different syndrome types were treated with the treatment group.After comparing the improvement of TCSS Score,the effective rate of the Phlegm and Blood Stasis group was 83.9%,the effective rate of Yang Deficiency and Blood Stasis type was 93.5%,and the effective rate of Qi Deficiency and Blood Stasis group was 76.4%.The TCSS Scores in the Yang Deficiency and Blood Stasis group were better than those in the Phlegm and Blood Stasis group and the Qi Deficiency and Blood Stasis group(P<0.05,P<0.05,P<0.05).There was no significant difference in the improvement of TCSS Scores between the Phlegm and Blood Stasis group and the Qi Deficiency and Blood Stasis(P>0.05).5.The mean age,duration of diabetes,and duration of DPN in the three groups of patients with different syndromes were different(P<0.05).The patients with Yang Deficiency and Blood Stasis type were longer than Qi Deficiency and Blood Stasis type and the Phlegm-Blocking type(P<0.05,P<0.05).There was no significant difference between the Qi Deficiency and Blood Stasis type and the Phlegm-Blocking type(P>0.05).6.There were significant differences in random blood glucose and glycosylated hemoglobin(HbAlc)between the three groups of patients with different types of DPN(P<0.05).Patients with Yang Deficiency and Blood Stasis type were higher than the Qi Deficiency and Blood Stasis type and the Phlegm-Blocking type in random blood glucose and HbAlc(P<0.05,P<0.05).There was no difference between the Qi Deficiency and Blood Stasis type and the Phlegm-Blocking type(P>0.05).Conclusion:1.QiangHuo Exterior Washing can significantly improve the clinical symptoms and signs of patients with different syndromes of DPN;2.QiangHuo Exterior Washing is more effective in improving the symptoms of Yang Deficiency and Blood Stasis type,superior to Phlegm and Blood Stasis and Qi Deficiency and Blood Stasis type,QiangHuo Exterior Washing and is more suitable for DPN patients with Yang Deficiency and Blood Stasis type.