| Objective:By observing the effect of Rukang Shengxue ointment on cancer-related fatigue symptoms and quality of life of breast cancer patients during chemotherapy,the clinical efficacy and safety of Rukang Shengxue ointment in improving cancer-related fatigue during chemotherapy of breast cancer were evaluated,and a simple and effective method for improving cancer-related fatigue of breast cancer was provided.Methods:74 breast cancer patients who met the inclusion criteria were randomly divided into two groups,Rukang Shengxue Ointment group and blank control group,37 cases in each group.On the basis of routine chemotherapy,the plaster group was given Rukang Shengxue ointment and health guidance during chemotherapy.The plaster was administered 20 g/time twice a day and 1-21 days after chemotherapy(3 weeks).The control group was given health guidance only during chemotherapy.The changes of PFS fatigue scale score,QOL scale score and KPS scale volume were observed before and after treatment.The changes of scores and adverse reactions during treatment were recorded.Statistical analysis of data and evaluation of clinical efficacy and safety of Rukang Shengxue Ointment in improving cancer-related fatigue during breast cancer chemotherapy.Results:1.The results of PFS scale comparison among groups showed that in the first week,each dimension and total score of the two groups were higher than before treatment,while the increase of emotional and sensory dimension and total score of the plaster group was smaller than that of the control group(P<0.05),while there was no significant difference in behavioral and cognitive dimension(P>0.05).In the 2nd and 3rd weeks of treatment,the scores of each dimension in both groups decreased,but the decrease of emotional,sensory,behavioral and total scores in the.ointment group was greater than that in the control group(P<0.05),indicating that the improvement of emotional,sensory and behavioral dimensions in the ointment group was better than that in the control group.For cognitive dimension,there was significant difference only in the third week between the two groups(P<0.05),and the effect of the same ointment group was better than that of the control group.The total score of the two groups after 3 weeks of treatment showed that the ointment group was better than the control group in improving fatigue in general(P<0.05).2.The comparison of PFS scale dimensions and total scores before and after treatment showed that the scores of behavioral,emotional,sensory,cognitive dimensions and total scores increased in the first week of treatment,and there was no significant difference compared with before treatment(P>0.05).The scores of behavioral,emotional,sensory dimensions and total scores began to decrease in the second week of treatment,which was significantly different from those before treatment(P<0.05).Cognitive dimension scores also decreased from the second week of treatment,but there was no significant difference compared with before treatment(P>0.05).At the third week of treatment,the scores of behavioral,emotional,sensory and cognitive dimensions and total scores continued to decrease,which was significantly different from those before treatment(P<0.05).From the results of the total score,the degree of fatigue of patients showed a downward trend from the 2nd week on the whole,indicating that Rukang Shengxue Ointment could improve fatigue to some extent.3.Comparing the dimensions and total scores of PFS scale before and after treatment in the control group showed that the average scores of each dimension and total score in the control group were higher than those before chemotherapy in the first week of treatment,and there was no significant difference in cognitive dimension between before and after chemotherapy(P>0.05).The other dimensions were significantly different from those before chemotherapy(P<0.05),suggesting that fatigue was worse than before treatment.The scores of all dimensions in the second week of treatment were lower than those in the first week of treatment,but there was no significant difference compared with those before chemotherapy(P>0.05).In the third week of treatment,the scores of emotion,behavior,sensation,cognition and total score continued to decrease,but there was no significant difference compared with before chemotherapy(P>0.05).4.The comparison of quality of life between the two groups showed that:the quality of life of the two groups was lower than that before chemotherapy,and the ciecline of plaster group was less than that of the control group,but there was no significant difference between the two groups(P>0.05);from the second week of treatment,the scores of physical function,emotional function,general health,pain,shortness of breath,fatigue,nausea and vomiting,insomnia,loss of appetite,diarrhea,pain,shortness of breath and constipation were scored in the two groups.There was a significant difference between the two groups(P<0.05).The comparison between the two groups indicated that the improvement of the ointment group was greater than that of the control group.For the cognitive function dimension,the two groups had the same effect in the second week(P>0.05),and there was a significant difference in the third week(P<0.05),and the improvement of the ointment group was greater than that of the control group.There was no significant difference between the other dimension groups(P>0.05).5.The quality of life of the plaster group before and after treatment showed that the overall health score of the plaster group in the first week of treatment was lower than that before treatment,and the scores of other dimensions were higher than that before treatment.There was no significant difference in the scores of fatigue symptoms between before and after treatment(P>0.05),while the scores of other dimensions were significantly different from those before treatment(P<0.05),suggesting that the quality of life of the plaster group in the first week after chemotherapy was better than that of treatment.The former has declined.After the second week of treatment,the scores of physical function,emotional function,insomnia,nausea and vomiting,loss of appetite,fatigue,pain,shortness of breath and total health status began to improve,which were significantly different from those before treatment(P<0.05).The improvement of cognitive function began at the 3rd week of treatment(P<0.05),while the improvement of other dimensions was not significant(P>0.05).6.The quality of life of dimensions before and after treatment showed that the total health status score of the control group decreased in the first week of treatment compared with that before treatment,while the other dimensions score i ncreased in comparison with that before treatment(P<0.05),indicating that the quality of life of the control group decreased in the first week after chemotherapy compared with that before treatment.In the second week of treatment,the total health status score began to rise slowly,while the other dimensions began to decline slowly,but there was no significant difference compared with before treatment(P>0.05).In the third week of treatment,only the scores of pain,shortness of breath,insomnia and loss of appetite were significantly different from those before treatment(P<0.05),while the scores of other dimensions were not significantly different from those before treatment(P>0.05).7.The comparison of KPS scores before and after treatment showed that the KPS scores of the two groups after 3 weeks of treatment were higher than the precondition,and there was statistical difference between the two groups(P<0.05).Compared with the control group,the KPS score of the ointment group was significantly higher than that of the control group,and there was a statistical difference between the two groups(P<0.05).8.In the ointment group,there were 3 cases of adverse reactions related to the use of ointment during the treatment period,including 2 cases of slight dry mouth and sore throat,and 1 case of mild gingival pain.The symptoms could be alleviated by reducing dosage and symptomatic treatment.There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion:1.On the basis of routine chemotherapy and health guidance during chemotherapy,Rukang Shengxue Ointment can effectively reduce the degree of cancer-related fatigue during chemotherapy for breast cancer.2.Rukang Shengxue Ointment can effectively improve the quality of life of patients with breast cancer-related fatigue during chemotherapy.3.Rukang Shengxue Ointment combined with routine chemotherapy and health guidance during chemotherapy can effectively improve the physical condition of cancer patients.4.During the treatment of Rukang Shengxue Ointment,the adverse reactions related to the use of the ointment prescription included dry mouth,sore throat and gingival pain,mostly mild,no serious adverse reactions and good safety. |
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