Correlation Analysis Of The Status Of Thethrombus And The Influence Factors In Different Syndrome Types Of R Ecurrent Spontaneous Abortion

ObjectiveTo investigate the correlation between TCM syndrome types of recurrent spontaneous abortion,the state of thrombosis.Method151 cases of patients with recurrent spontaneous abortion visiting the doctor in the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine from February 2018 to January 2019 conducted a questionnaire survey on TCM syndrome differentiation typing,general condition,Menstrual situation,childbearing history,living habits,psychological factors,Sleep quality and Physical activity.150 normal women of childbearing age were selected as control group and conducted the same questionnaire survey.The status of thrombus in patients with recurrent spontaneous abortion was detected.Statistical processing was performed using SPSS20?The measurement data conforming to the normal distribution are expressed as mean standard deviation(x± s)?The homogeneity test of variance was carried out on the measurement data conforming to normal distribution?Bonferroni test was used for the difference?T2 test was used for variance inhomogeneity?Mean rank sum quartile and median(P25,P50,P75)were used to represent the samples that did not conform to the normal distribution,and the rank sum test was used?The correlation between each syndrome type of prethrombotic state was analyzed.Univariate and multivariate Logistic regression(stepwise method)were used to analyze the pathogenesis factors of various TCM syndromes of recurrent abortion.P<0.05 was considered statistically significant.Result1.Distribution of TCM syndromes of recurrent abortion:kidney deficiency and blood stasis syndrome in forty cases;kidney deficiency syndrome in thirty-seven cases,spleen and kidney deficiency in forty-eight cases,Qi and blood deficiency syndrome in twenty-two cases?2.There were no statistically significant differences among groups of Protein C,Protein S,Antithrombin III,D-dimer,Anticoagulant antibody,Lupus anticoagulant,Anti-2-GP1 in different types of recurrent abortion(P<0.05).The HCY of kidney deficiency and blood stasis syndrome group with recurrent spontaneous abortion was higher than other syndromes(P<0.05).3.The risk factors of kidney deficiency syndrome included education level(OR=4.889,P=0.009),menstrual disorder(OR=3.497,P=0.001),number of induced abortion(OR=4.324,P=0.019)(OR=7.410,P=0.003)?4.The risk factors of kidney deficiency and blood stasis syndrome included number of induced abortion(OR=3.857,P=0.012),depression(OR=1.058,P=0.031).5.The risk factors of Qi and blood deficiency syndrome included sleep quality(OR=6.545,P=0.016),exercise quantity(OR=4.739,P=0.040)?6.The risk factors of spleen and kidney deficiency included exercise quantity(OR=4.594,P=0.004),anxiety(OR=1.335,P=0.000)and depression(OR=1.395,P=0.000).Conclusionkidney deficiency and blood stasis is related to the pre-state of thrombus.Different syndrome types of recurrent spontaneous abortion were relevant to educational background?menstrual disorder?Induced abortion?anxiety?depression?physical exercise and sleep quality?...