| Objective:This study was to observe the clinical efficacy of Professor Gao Jining's experience“Yi Shen Ning”in the treatment of chronic glomerulonephritis(spleen-kidney qi deficiency type)and objectively evaluate its curative effect,and provide“Yi Shen Ning”for the treatment of chronic glomerulonephritis clinical evidence of efficacy and safety in order to further promotion and application.Methods:1.Subjects:66 patients with chronic nephritis,spleen and kidney qi deficiency,which meet the inclusion criteria,were numbered according to the treatment order and grouped by random methods,with 33 cases in each group.2.Research methods:Both groups are given general conventional treatment for chronic nephritis in modern medicine,including general education of nephropathy,active control of blood pressure,blood lipids,application of glucocorticoids and cytotoxic drugs,restriction of protein and phosphorus intake,and antiplatelet therapy if necessary.Symptomatic treatment.On the basis of the above treatment,the treatment group was treated with“Yi Shen Ning”Decoction and the control group was given the nephritis rehabilitation tablets.The relevant efficacy and safety indicators were observed before treatment,after 6 weeks and 12 weeks.3.Observed indicators include:patient symptom scores and physical and chemical indicators such as routine testing of urinary protein,24-hour protein quantification,hematuria,creatinine and urea nitrogen etc.,so as to objectively evaluate the clinical efficacy of Yishen-Ningfang.If there are adverse reactions,record it in time.Results:1.Total effective rate:After 6 weeks of treatment,the effective rate in the treatment group was 81.81%and the effective rate in the control group was 63.63%,the difference was not statistically significant(P>0.05);after 12 weeks of treatment,the effective rate in the treatment group was 93.94%,the effective rate in the control group was 72.72%,and the difference was statistically significant(P<0.05).2.Clinical curative effect:After 6 weeks of treatment,compared with before treatment,the symptoms and signs of the patients in the treatment group and the control group all improved.The difference was statistically significant(P<0.05).After 12 weeks of treatment,the treatment was compared with that before the treatment.The symptoms and signs of the patients in the group and the control group were significantly improved(P<0.01)and the effect of the treatment group was better than which of the control group.3.Proteinuria and renal protection:Before treatment,the 24-hour urine protein quantification mean:1.97±0.89g/24h in the control group and 1.98±1.04g/24h in the treatment group;24-hour urine protein quantification after 6 weeks of treatment were followed:control group 1.78±1.05g/24h,treatment group 1.82±1.05g/24h;after 12weeks of treatment,24-hour urine protein quantification mean:control group 1.25±0.91g/24h,treatment group 0.77±0.47 g/24h;Before treatment and after 6 weeks of treatment,treatment group:t=0.599,~?P=0.05,control group:t=0.806,~?P>0.05;before treatment and after 12 weeks of treatment,treatment group:t=6.046,~?P<0.01,control group:t=3.218,~?P<0.01;after 12 week treatment group compared with the control group,t=-2.699,~?P<0.01.There was no significant difference in 24-hour urinary protein excretion(UAER)between the treatment group and the control group before treatment and after the 6th weekend after treatment(~?P>0.05);the treatment group was treated on the 12th weekend after treatment compared with before treatment.The UAER in the control group was significantly decreased(~?P<0.01),and the improvement was more significant in the treatment group than in the control group(~?P<0.01).There was no abnormal change in urea nitrogen(BUN)and serum creatinine(Scr)before and after treatment.Conclusion:From the above results,in the basic medical treatment,compared with the use of nephritis rehabilitation tablets,“Yi Shen Ning”can more significantly improve the symptoms and signs of patients with chronic nephritis,can effectively reduce urine protein.Not only do have a certain role of kidney protection,but also has a certain value of promotion and application. |
PDF Full Text Request