| OBJECTIVE: The purpose of this study was to observe the clinical efficacy of Ganluyin in the treatment of chronic kidney disease with stage 4-5damp-heat injury and Yin syndrome,and to analyze its effects on renal function,inflammatory factors and TCM syndrome scores,and to explore the treatment of Ganluyin.The mechanism and advantages of chronic kidney disease 4-5 wet heat injury yin syndrome provide a theoretical basis for the treatment of chronic kidney disease by Chinese medicine.METHODS: 64 ckd4-5 patients with negative syndrome of dampness and heat injury who met the inclusion criteria were randomly divided into the treatment group and the control group.The treatment group received basic treatment + ganlu Yin plus or minus TCM formula granules,while the control group received basic treatment + niuduqing granules.Treatment was observed for 8 weeks.Hemoglobin(Hb)was observed in both groups.Renal function:serum creatinine(Scr),blood urea nitrogen(BUN),serum cystatin C(cys-c),glomerular filtration rate(eGFR).Inflammatory factors: serum hypersensitive c-reactive protein(hs-crp),serum tumor necrosis factor-alpha(tnf-alpha),serum interleukin-6(il-6),and the total curative effect,TCM syndrome curative effect,TCM syndrome score,and main clinical symptom score before and after treatment.RESULTS: 1.Total efficacy: the total effective rate of the treatment group was 87.1%(27/31),which was 62.1%(18/29)better than that of the control group,showing a significant statistical difference(P < 0.01).2.TCM syndrome efficacy: the total effective rate of the treatment group was 93.5%(29/31),which was better than the effective rate of the control group(72.4%(21/29),showing a significant statistical difference(P < 0.01).3.Total score of TCM syndromes: after treatment,both groups were significantly lower than before treatment,with significant statistical difference(P < 0.01);After treatment,the treatment group wassignificantly better than the control group,with significant statistical difference(P < 0.01).4.Main clinical symptoms: the treatment group was significantly better than the control group in improving nausea,vomiting,dry mouth and dry pharynx,with statistically significant differences(P < 0.01).5.Hemoglobin(Hb): after treatment,it was significantly higher than before treatment in the treatment group,with a significant statistical difference(P < 0.01).After treatment,the control group was significantly higher than before treatment(P < 0.05).After treatment,the treatment group was better than the control group,with statistical difference(P < 0.05).6.Renal function(Scr,BUN,cys-c,eGFR): serum levels of Scr,BUN,cys-c in the two groups were significantly decreased after treatment compared with those before treatment,with significant statistical difference(P < 0.01).After treatment,the treatment group was significantly better than the control group in reducing serum Scr,with a statistically significant difference(P < 0.01);the treatment group was better than the control group in reducing serum BUN and cys-c,with a statistically significant difference(P < 0.05).EGFR was significantly increased after treatment compared with before treatment in the treatment group,with statistically significant difference(P < 0.01).EGFR in the control group increased after treatment compared with before treatment,with statistically significant difference(P < 0.05).Comparison of the two groups after eGFR treatment showed that the treatment group was better than the control group,with statistically significant difference(P < 0.05).7.Inflammatory factors(il-6,tnf-alpha,hs-crp): serum levels of il-6,tnf-alpha and hs-crp in the two groups were significantly decreased after treatment compared with those before treatment(P < 0.01).There were significant differences in il-6 and hs-crp between the two groups after treatment(P < 0.01).There were statistically significant differences between the two groups after TNF-a treatment(P < 0.05).CONCLUSION: 1.Ganluyin addition and reduction formula can significantly improve the clinical symptoms of ckd4-5 patients with Yin syndrome of damp-heat injury,such as nausea and vomiting,dry mouth and pharynx.2.Ganluyin addition and reduction formula can improve the hemoglobin level and improve the nutritional status of ckd4-5 patients with Yin syndrome of damp-heat injury.3.Ganlu decoction addition and reduction formula can reduce serum Scr,BUN and cys-c levels in ckd4-5 patients with Yin syndrome of damp-heat injury,improve glomerular filtration rate and protect residual renal function.4.Ganlu decoction can reduce serum tnf-a,il-6 and hs-crp levels in ckd4-5 patients with negative syndrome of damp-heat injury,and improve the state of micro-inflammation. |
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