Association Of Platelet Distribution Width And Plasma D-dimer Levels With Coronary Artery In Patients With Coronary Disease

Objective Many studies have reported that platelet activation and hyperfibrinolysis was closely related to the occurrence,development,and prognosis of coronary heart disease.Platelet distribution width(PDW)is highly sensitive and specific to platelet activation,and the plasma D-dimer is considered to be a fibrinolytic product.The aim of this study is to explore the association of platelet distribution width and plasma D-dimer levels with coronary artery in patients with coronary disease.Methods Two hundred patients undergoing coronary angiography were collected from the Second Hospital of ** from January 2016 to May 2018,and divided into stable angina pectoris(SAP,n=70)group,unstable angina pectoris(UAP,n=73)group,and acute myocardial infarction(AMI,n=57).All patients were divided into low Gensini score group(< 41,n=94),intermediate Gensini score group(41 ~87,n=68),and high Gensini score group(>87,n=38).The levels of PDW and D-dimer were analysed by the routine blood test and coagulation function of patients.The association of PDW and plasma D-dimer levels with the degree of coronary stenosis in CHD patients was assessed by comparing the difference of general clinical and laboratory data.Results Compared with the low and intermediate Gensini score group,the levels of PDW and plasma D-dimer were significantly greater in high Gensini score group(P< 0.05).The Gensini scores,PDW and D-dimer levels in AMI group were higher than that of SAP and UAP groups(P < 0.01).Pearson and Spearman correlation analysis showed that the levels of PDW and plasma D-dimer was correlated with the Gensini score in patients with coronary disease(r=0.497 ? 0.278,P < 0.01).Multivariate Logistic regression analysis showed that the levels of PDW and plasma D-dimer were independently correlated with the coronary artery disease in patients,respectively.Conclusion The data show that PDW and plasma D-dimer levels are independently correlated with the coronary artery disease in patients,and the higher levels of PDW and plasma D-dimer are associated with more severe coronary lesions.