| Objective:To discuss the differences of inflammatory markers and improvement of symptoms between the western medicine treatment and western medicine treatment combined with modified Qingfei Huatan Decoction in treating patients with AECOPD of phlegm heat obstructing lung syndrome,to clarify whether modified Qingfei Huatan Decoction could improve symptoms and quality of life?synergize with other antibiotics to resist infection and evaluate its safety.Methods:A total of 60 hospitalized patients treated in the Jiangsu Provincial Hospital of Integrated Traditional and Western from December 2017 to December 2018 with phlegm heat obstructing lung syndrome of AECOPD were randomly divided into a control group and a Traditional Chinese Medicine(TCM)treatment group with 30 cases in each.The control group were treated with routine western medicine(respiratory support,bronchiectasis,antibiotics,glucocorticoids,etc.),the TCM treatment group treated by Modified Qingfei Huatan Decoction on the basis of the control group(7 day a course,one dose per day,twice a day).Record the data of inflammatory markers(WBC,PCT,CRP),arterial blood gas analysis(PaO2,PaCO2),TCM symptom score,mMRC,CAT score,safety indicators(ALT,AST,Cr,BUN)at the 1st day and 5stą1 day.Results:1.There was no statistically significant differences between the two groups in age/sex ratio,acute exacerbation time and the score of each index before treatment(P>0.05),the two groups were balanced and comparable.2.There was no statistically significant differences between two groups in the respect of within-group comparison after treatments(P>0.05),the differences of between-group comparison were no statistically significance either(P>0.05).In the respect of the level of CRP,the differences of within-group comparison had high statistical significance after treatments(P<0.01),the improvements of the experimental group were better than control group(P<0.05).3.After treatment,the levels of PaO2 in the two groups were significantly different from before(P<0.01),the level of PaO2 increased.There were no significant between-group comparison differences between the TCM treatment group and the control group after treatment(P>0.05).The level of PaCO2 had no statistical significance between two groups neither between-group comparison differences nor within-group comparison differences(P<0.05).4.The total score of TCM symptoms,main symptom's score and every main symptom's score of the two groups was significantly different compared with that before treatment in the respects of between-group comparison and within-group comparison(P<0.05),and the scores were down from the previous one.The improvements of the experimental group were better than control group(P<0.05).5.The between-group comparison differences of two groups were statistically significant in the respect of the level of dyspnea rating scales(P<0.05),the grades were lower than before,and the within-group comparison of two groups had no statistical significance(P>0.05).6.The between-group and within-group comparison differences of two groups were statistically significant in the respect of the level of CAT scores(P<0.01),The improvements of the experimental group were better than control group(P<0.05).7.The between-group and within-group comparison differences of two groups were no statistically significant in the respect of the level of safety indicators,and the safety indicators were aspartate aminotransferase(AST),alanine aminotransferase(ALT),blood urea nitrogen(BUN),creatinine(Cr)(P>0.05).Conclusion:1.Treating AECOPD of phlegm heat obstructing lung syndrome with modified Qingfei Huatan Decoction can make further efforts to reduce the level of CRP and synergize with other antibiotics to resist infection.2.Treating AECOPD of phlegm heat obstructing lung syndrome with modified Qingfei Huatan Decoction can improve the TCM symptoms,patients'quality of life and curative effects.3.Modified Qingfei Huatan Decoction has no side effects and toxicities of liver and kidney,it has clinical feasibility. |
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