Correlation Between Vascular Cognitive Impairment And Serum Aβ1-42 And Analysis Of TCM Syndromes

Objective:Through the analysis of serum Aβ1-42 and TCM syndromes in patients with vascular cognitive impairment,the correlation between different degrees of dementia and Aβ1v-42 was observed,and the distribution regularity of TCM syndromes was analyzed,and some references were attempted to provide for the diagnosis and differentiation of TCM syndromes of this disease,and to provide guidance for specific clinical practice.Methods:According to the inclusion criteria and exclusion criteria,the diagnostic criteria for vascular cognitive impairment refer to the Guidelines for Diagnosis Treatment of Vascular Cognitive Impairment(2011 edition),the TCM syndrome criteria refer to the criteria for diagnosis,differentiation of symptoms and evaluation of curative effect of vascular dementia(research application)formulated by Tian Jinzhou in 2002,200 patients with vascular cognitive impairment treated in Jiangsu Provincial Hospital of Chinese Medicine are choosed.Montreal Cognitive Assessment,Clinical Dementia Rating and HIS Ischemia Assessment Scale were used to evaluate 200 eligible patients,and informed consent was signed after describing the general situation of the study,general data were collected,and TCM syndromes were scored.The serum was separated by centrifugation for 15 minutes at 2000 r/min.The serum was stored in refrigerator at-80 C.The serum Ap 1-42 level was detected by ELISA.Then the data were collected and analyzed by SPSS software.Result:1.Serum Aβ1-42 analysis:Serum samples from 200 VCI patients and 30 non-dementia controls were tested.We found that there was a weak negative correlation between serum Aβ1-42 level and the severity of dementia in VCI patients(P<0.05).2.Analysis of TCM syndromes:The order of occurrence frequency of TCM main syndromes in patients from high to low is:kidney essence deficiency syndrome(37%),bl stasis syndrome(24%),phlegm turbidity obstruction syndrome(19.5%),liver yang hyperactivity syndrome(10%),fu-organ excess syndrome(7.5%),heat toxicity syndrome(1%)Qi and bl deficiency syndrome(1%).Because many patients have concurrent syndromes,we analyzed all the syndromes(including main syndromes and concurrent syndromes).The frequency of occurrence is:kidney essence deficiency syndrome(53%),blood stasis syndrome(50.5%),phlegm turbidity obstruction syndrome(41%),fu-organ excess syndrome(20%),Qi and bl deficiency syndrome(11%),of liver Yang hyperactivity syndrome(10%)heat toxicity syndrome(10%).The most frequent combination of two syndromes is:kidney essence deficiency syndrome+blood stasis syndrome(16%),phlegm turbidity obstruction syndrome+blood stasis syndrome(13%),kidney essence deficiency syndrome+phlegm turbidity obstruction syndrome(12%).The combination of the three syndromes only appeared:kidney essence deficiency syndrome + phlegm turbidity obstruction syndrome + blood stasis syndrome(9.5%).In VCI patients,there are 7 single types of TCM syndromes,a total of 28 cases,accounting for 14%;11 combinations of the two syndromes,a total of 153 cases,accounting for 76.5%;only one combination of the three syndromes,a total of 19 cases,accounting for 9.5%Conclusion:1.There was a weak negative correlation between serum Aβ1-42 level and dementia degree in VCI patients(P<0.05),This suggests that the more serious the dementia degree is in this study,the lower level of serum Aβ1-42.This may be related to the abnormal deposition of Aβ1-42 in the brain leading to the decrease of peripheral concentration.2.Kidney essence deficiency syndrome,blood stasis obstruction collateral syndrome and phlegm turbidity obstruction orifice syndrome are the main syndromes of patients with vascular cognitive impairment,and the combination of these three syndromes is also the main syndrome combination.The results of this study basically accord with the understanding of the main pathogenesis of the disease in TCM theory,and can provide certain guidance for TCM diagnosis and treatment of VCI.