Analysis On Clinical Characteristics Of 85 Hospitalized Patients With Ulcerative Colitis

Objective: To retrospectively analyze the clinical records of patients with different clinical types of active ulcerative colitis who has received Hp test in our hospital during the past ten years,summarize the different characteristics of initial ulcerative colitis and chronic recurrent ulcerative colitis,and provide a certain reference for the diagnosis and treatment of ulcerative colitis in different clinical types.Methods: To collect the clinical data of 85 active UC patients who were hospitalized in the Department of Digestive Medicine from September 2008 to September 2018,and receive 13 C exhalation test,14 C exhalation test or tissue biopsy staining during the onset.Among them,there were 33 cases of initial ulcerative colitis and 52 cases of chronic recurrent ulcerative colitis.The data including sex,age,nationality,clinical symptoms,complications,parenteral manifestations,main laboratory results,endoscopic findings and pathology,lesion extent,severity of disease,treatment plan and so on were recorded.Statistical software SPSS21.0 was used to process the data,and the countingdata was expressed by percentage.Chi-square test was used to compare the difference between two or more sample rates.The measurements were expressed as ? ? ±s,and the mean values between the two groups were compared by independent sample t test.Results: 1.General information:A total of 85 cases were included in the study,and the ratio of male to female was 1.24:1.The number of males with initial UC and chronic recurrent UC was higher than that of females.The most common age of disease is between 40 and 49 years old.Initial UC patients of all ages were more evenly distributed,and chronic recurrent UC patients were mostly middle-aged patients.There was no significant difference in ethnic composition between the two groups.2.Clinical manifestation: Abdominal pain,diarrhea,mucopurulent bloody stool,emaciation,tenesmus were the main clinical manifestations of patients in both groups,while abdominal distension,fever,anemia and fatigue were rare.Chronic recurrent UC is more common than initial UC in parenteral manifestations.The symptoms of mucopurulent bloody stool and tenesmus are more serious than those of primary UC,and the difference is statistically significant.3.Pathogenetic condition: Chronic recurrent UC is more common in moderate and severe activities,and initial UC is more common in mild activities.The difference between the two groups is statistically significant.4.Scope of lesions: There was no significant difference in the scope of lesions between patients with chronic recurrent UC and those with initial UC.5.Laboratory tests: The C-reactive protein and platelet levels of chronic recurrent UC were significantly higher than those of initial UC,and the HDL level was lower than that of initial UC.The difference was statistically significant.There was no significant difference in HP infection between initial UC and chronic recurrent UC.6.Enteroscopy and pathology: Both initial UCand chronic recurrent UC presented diffuse vascular texture blurring,hyperemia,edema,embrittlement,spontaneous bleeding,erosion,ulcer and exudation of purulent secretions,which were consistent with the changes of UC in the active stage.The rate of pseudopolyp formation in chronic recurrent UC was significantly higher than that in initial UC,and the difference was statistically significant.Pathological manifestations of both groups were acute and chronic inflammatory cell infiltration,mucosal erosion and superficial ulcer formation,and there was no significant difference between the two groups.7.Treatment:Initial UC and chronic recurrent UC patients were all treated with5-aminosalicylic acid preparation,local glucocorticoid enema and probiotics.The most commonly used drug was 5-aminosalicylic acid preparation.Among oral/intravenous glucocorticoids,the number of chronic recurrent UC patients was significantly higher than that of initial UC patients,and the difference was statistically significant.Thalidomide,azathioprine and infliximab are more commonly used in chronic recurrent UC.Conclusions: 1.Chronic recurrent UC patients are more common in moderate and severe activities,and clinical manifestations are abdominal pain,diarrhea,mucopurulent bloody stool,wasting,and tenesmus.In addition,the symptoms of mucopurulent bloody stool,tenesmus and extraintestinal manifestations are more obvious than those of the initial hair UC.2.The CRP level of chronic recurrent UC was significantly higher than that in patients with primary UC,suggesting that CRP may be a good predictor of recurrence of UC.3.The platelet level of chronic recurrent UC was significantly higher than that of initial UC,suggesting that elevated PLT level may be a risk factor for UC recurrence.4.Chronic recurrent UC had lower HDL level than initial UC,suggesting that declined HDL level may be a risk factor for UC recurrence.5.The HP infection rate in patients with chronic recurrent UC is higher than that of the initial UC,but the difference is not statistically significant.At present,HP can not be considered as a risk factor for UC recurrence.