Analysis Of Risk Factors Of Osteoporosis In Middle-aged Elderly Patients With Type 2 Diabetes

Objective: To study the risk factors of type 2 diabetes mellitus(T2DM)complicated with osteoporosis in middle-aged and elderly patients,and to provide theoretical basis for early prevention of osteoporosis.Methods:Total of 225 T2DM patients who were hospitalized in the Department of Endocrinology,the first affiliated Hospital of Guangxi Medical University from August 2016 to October 2018 were selected.According to the results of bone mineral density,the patients were divided into non-osteoporosis group.Group NOP(n=128)and osteoporosis group(OP group,n=97).The general data of the two groups were compared,such as sex ratio,age,BMI,course of diabetes,age of menopause,etc.Hemoglobin(Hb),total bilirubin(TBIL),glutamic alanine aminotransferase(ALT),albumin(ALB),prealbumin(PA),glutamyl transpeptidase(GGT),alkaline phosphatase(ALP),serum calcium(Ca)and serum phosphorus(P)were compared.Serum uric acid(SUA),serum creatinine(Scr),cystatin.C(CysC),retinol binding protein 4(RBP4),total cholesterol(TC),triglyceride(TC),high density lipoprotein cholesterol(HDL-C),Low density lipoprotein cholesterol(HDL-C),homocysteine(HCY),glycosylated hemoglobin(HbA1c),fasting blood glucose(FBG),2 hours postprandial blood glucose(2hPBG),fasting C peptide(FCP)and 2 hours postprandial C peptide(2hCP),25hydroxyvitamin D3(25(OH)D3)were observed.The difference analysis and correlation analysis between groups were carried out.Results: 1.There were significant differences in age,course of diabetes,age of menopause,BMI,Hb,ALT,ALP,PA,SUA,P,HDL-C and HbA1 c between OP group and non-OP group(P < 0 05).There was no significant difference in sex constituent ratio between the two groups(P > 0 05).2.The results of correlation analysis showed that the overall BMD value of femoral neck and hip was positively correlated with BMI,female menopausal age,Hb,ALT,PA and SUA,but negatively correlated with patient age and HbA1 c level.The BMD of femoral neck was positively correlated with the level of 25(OH)D3,but negatively correlated with the course of diabetes and ALP(P < 0 05).The BMD of hip was positively correlated with GGT,but negatively correlated with HDL-C(P < 0 05).The overall BMD of lumbar vertebrae was positively correlated with BMI,menopausal age,Hb,ALT,SUA and Scr,but negatively correlated with the course of diabetes,ALP,HbA1 c and HDL-C.3.The results of binary logistic regression analysis showed that aging and the increase of ALP level suggested that T2 DM complicated with OP was a risk factor,while BMI was a protective factor for bone mass loss.Conclusion:Old age,high ALP and low body mass index are the risk factors of osteoporosis in middle-aged and elderly patients with type 2 diabetes mellitus.