| Objective To investigate the changes of lumar vertebrate bone mineral density(BMD)and its related factor in patients with type 2 diabetes mellitus(T2DM).Methods quantitative CT(QCT) was used to measure BMD of lumbar spine in 127 patients with T2DM aged 50-82 years and 89 healthy subjects(control group). The age,sex and body mass index(BMI) in patients with T2DM were compared with control group.The BMD of lumbar spine and prevalence rate of osteporosis(OP) in patients with T2DM were compared with normal subjects.Three groups were disparted as different diabetic duration, the BMD of lumbar spine in patients with T2DM were compared in every group.The correlation of BMD in T2DM with age, diabetic duration,BMI, menopausal age,and duration after menopausal were analysis.Results①The age,sex and BMI were similar to those in the conrol group(P>0.05).②The BMD of L1-3 in the T2DM group were similar to those in the control group (P>0.05).③The BMD of lumar spine in the male T2DM were similar in every diabetic duration group(P>0.05).The BMD of L2 in the female T2DM diabetic duration>10 years group was significantly decreased compared with it in the<5 years group (P<0.05).④The prevalence rate of OP in the T2DM group were similar to those in the control group (P>0.05).⑤In male T2DM group, the BMD of lumabar spine had significantly correlation with age(r=-0.610,P<0.05),and had significantly correlation with BMI(r=0.158,P<0.05).After adjusting age, the BMD of lumabar spine in male T2DM group had no correlation with duration(r=-0.014,P>0.05).⑥In female T2DM group, the BMD of lumabar spine had significantly correlation with age(r=-0.669,P<0.05),and had significantly correlation with BMI(r=0.259,P<0.05).After adjusting age, the BMD of lumabar spine in female T2DM group had no correlation with duration(r=-0.048,P>0.05).⑦fter adjusting age,BMD in female T2DM group had no correlation with menopausal age,and had significantly partial correlation with duration after menopausal[r=-(0.157-0.216),P<0.05].Conclusions①The BMD of lumabar spine and the prevalence rate of osteoporosis in patients with T2DM were similar to those in the control group.②The reduction of BMD of lumar spine in patients with T2DM is more obvious accompanying with the increasing age.③The Reduction of BMD of lumar spine in the T2DM is more obvious accompanying with the decreasing BMI.④The BMD of lumar spine in the T2DM is unrelated with the desease duration..⑤The Reduction of BMD of lumar spine in the female T2DM is more obvious accompanying with the increasing duration after menopausal. |
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