The Preliminary Investigation Of The Relationship Between Bone Mineral Density And The Function Of Islet Cell In Type 2 Diabetic Patients

Objective: With the development of people's life quality and the extendibility of natural life, the morbidity of the diabetic mellitus and the osteoporosis is increasing. That Bone metabolism can be affected by different ways resulted from diabetes and the correlated metabolic disorders leads to the outcome of metabolic bone disease. Recent studies have demonstrated that an elevated risk of osteoporosis and fractures happen in diabetic subjects. The presence of osteoporosis in type 1 diabetes seems to be reliable evidence. On the other hand, there is still some controversy about the risk of osteoporosis in type 2diabetes. Although the pathogenic mechanisms are not fully understood, damage of the islet cell function is considered as an important factor leading to the bone loss in diabetes. Insulin is regarded as one of the important factors that modulate the bone formation in the body, which plays an important role in the aspects of restoring the bone mass and preventing from the bone loss. All the people of diabetes exist the defect of effect on insulin. Insulin secretion is absolutely absent in type 1 diabetes, but in type 2 diabetes, it is possible that people have the insufficient insulin secretion or and the defect of insulin's effect.