| Objective To investigate the change of bone mineral density(BMD) in patients with type 2 diabetes(T2DM) and osteoporoses(OP) severity, analysis the related relative risk factor. Methods The BMD of 336 T2DM patients were measured, 2.5 standard deviation and 2 standard deviation below the peak value as the diagnosis standard of OP. Calculate the OP incidence of different age group. Compare and analyze the difference between OP group and non OP group in aspect of age, BMI, course, menopause time, blood glucose, hemoglobin A1c, serum insulin, C-peptide. Results There is statistics significance in patients over 50 years old using two kinds of diagnosis standard. If WHO diagnosis standard is used, the diagnosis incidence of OP is 8.9%; If 2.5 SD below peak value is used as diagnosis standard, the diagnosis incidence is 17.26%. 2) Using the 2 SD below peak value as diagnosis standard, there is significant difference of average BMI between OP group and non-OP group(p<0.05). 3) BMD is significantly negatively related to age(r=-0.359,p<0.01), positively related to body weight. (r=-0.434,p<0.01) BMD is also positively related to menopause time in female T2DM patients. 4) BMD is positively related to DM course only in 40-49 years old group(P<0.05). Conclusion It is more meaningful to use 2.0 SD below average as the diagnosis standard for the native T2DM patient; the BMD in T2DM patients is significantly positively related to patient's age, BMI and menopause time. Under 50 years old the longer the patient's DM course, the stronger the effect on the BMD. |
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