Clinical Observation On Treatment Of Hp Positive Chronic Gastritis Of Spleen Deficiency And Heat Syndrome By Flavored Xiangsha Liujunzi Decoction

Objective Comparison of TCM syndrome points before and after treatment,Clinical total effective rate,Hp eradicate rate,Hp recurrence,The degree of the disease changed before and after treatment,adverse reactions and so on.To discuss,to compare and to observe the clinical observation on treatment of Hp positive chronic gastritis of spleen-deficiency and damp-heat type by flavored Xiangsha liujunzi decoction and the Western medicine quadruple therapy.to provide ideas and methods for the treatment of Hp positive chronic gastritis with spleen-deficiency and damp-heat syndrome.Methods Selected January 2017 to January 2018 in Wuhan City Integrated Traditional Chinese and Western medicine hospital outpatient and inpatient cases,the C14-UBT are more than 100,Gastroscopy suggested chronic non-atrophic gastritis,and through TCM Syndrome Differentiation for 70 cases of spleen-deficiency and damp-heat syndrome.According to the order of visit,randomly divided into observation group and control group.In the observation group,3cases fell off during treatment,finally,32 cases were completed.In the control group,2 cases fell off,33 cases were completed in the last.The gender,age,gastritis classification,course of disease and severity of illness of the two groups were statistically analyzed,there were no statistical significance between them(P>0.05).After they having comparability,in the control group,33 patients were given quadruple therapy of western medicine:Clarithromycin sustained release tablets(0.5g bid),Amoxicillin clavulanate potassium tablets(0.95 g bid),Pantoprazole sodium enteric capsule(40mg bid),Colloidal bismuth capsules(0.2g bid).2 weeks is 1 course of treatment.In the treatment group,32 patients were treated with flavored xiangsha liujunzi decoction.Basic party:Radix pseudostellariae 20 g,Bran Fried atractylodes 15 g,Ginger pinellia 6g,Dried tangerine or orange peel 6g,Amomum villosum 6g,patchouli 15 g,dandelion 30 g,Wine radix scutellariae 8g,Rhizoma coptidis 3g,Cannon ginger 2g,Main licorice 6g.One dose daily,200 ml each time,take half an hour after meals in the morning and evening,4 weeks is a course of treatment.Ask clients to eat a light diet during treatment,try to eat alone with utensils,avoid cross infection,C-14 was reexamined one month after drug withdrawal at the end of all courses of treatment.To observe and compare the clinical total effective rate of the two groups,Hp eradicate rate,Hp recurrence,TCM syndrome points,the degree of the disease changed before and after treatment,adverse reactions,etc.Results1.Comparison of Hp eradication rate between the two groupsThe Hp eradication rate in the observation group(68.75%)was lower than that in the control group(87.88%),but the difference was not statistically significant(P>0.05),it may be related to the small sample size.2.Comparison of TCM syndrome efficacy between the two groupsThe total effective rate of the observation group(93.75%)was higher than that of the control group(84.85%),the difference was statistically significant(P<0.05).3.Comparison of TCM symptom scores between the two groupsBefore treatment,there was no significant difference in TCM symptom scores between the two groups,with no statistical significance(P>0.05).After treatment,all TCM symptom scores in the observation group and control group were lower than before,these results suggest that the two groups of drugs can improve the clinical symptoms of Hp positive chronic gastritis patients with spleen-deficiency and damp-heat syndrome.The total score of TCM symptoms in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).The results showed that the observation group had a significant advantage over the control group in improving the clinical symptoms of TCM patients.4.Comparison of Hp recurrence rates between the two groups After treatment,22 patients in the observation group and 29 in the control group turned negative with Hp.Review C14-UBT after half a year,the recurrence rates of observation group and control group were respectively 4.55%,17.24%,the difference was statistically significant(P<0.05).C14-UBT was reexamined again a year later,the recurrence rates of observation group and control group were respectively 9.09%,34.48%,the difference was statistically significant(P<0.05).The results showed that the long-term recurrence rate of Hp could be significantly reduced by the herb flavored xiangsha liujunzi decoction addition.5.Adverse reactions were compared between the two groupsA total of 2 patients in the observation group had adverse reactions,including 1 patient with nausea,retching,and 1 patient with diarrhea.A total of 8 patients in the control group had adverse reactions,including 3 cases of constipation,3 cases of diarrhea,and 2 cases of nausea and vomiting.The adverse reactions of the above patients were mild and did not reach the standard of shedding.They all improved or recovered after symptomatic treatment during the study.ConclusionThe traditional Chinese medicine flavored xiangsha liujunzi decoction and the western medicine four union therapy have the curative effect to the Hp positive chronic gastritis spleen-deficiency and damp-heat syndrome.But by comparison,Chinese medicine has obvious advantages for patients with Resistance to antibiotics,the patient with spleen deficiency of body,the patients with severe adverse reactions.It can improve the quality of life of patients,has high safety coefficient,and worthy of clinical application.