| ObjectiveTo observe the improvement of symptoms of Hp positive chronic gastritis patients with spleen deficiency and damp heat type treated by Huanglian Decoction of traditional Chinese medicine,and to explore the effectiveness of the treatment of chronic diseases,so as to provide a new idea for clinical treatment of Hp positive chronic gastritis with spleen deficiency and damp heat type.MethodFrom November 2018 to January 2020,70 patients who met the criteria of chronic gastritis and Hp positive diagnosis were randomly divided into test group and control group.The test group was given the granule preparation based on Huanglian Decoction(basic formula: Coptis 10 g,Rhizoma Pinelliae 10 g,Ramulus Cinnamomi 10 g,ginseng 10 g,dried ginger 10 g,roasted licorice 10 g,jujube 6),once a day,once in the morning and once in the evening,one hour after meal,for 4 weeks.The control group was given bismuth quadruple therapy,i.e.esmeralazole 20 mg bid,levofloxacin 0.2g Bid,clarithromycin 0.5g Bid,colloidal bismuth pectin 200 mg bid,once in the morning and once in the evening,the medication cycle is 14 days.To contrast and analyze the curative effect of TCM syndrome,TCM symptom score,quality of life,anxiety state,Hp eradication rate,numerical changes and adverse reactions of the two groups before and after treatment.Result1.Evaluation of TCM syndrome efficacyThe efficacy of TCM syndromes in the test group and control group were 96.87% and45.45%,respectively.The effect of syndrome in the test group was significantly stronger(P<0.05).2.Comparison of total scores of TCM symptomsThe test group and the control group almost no difference in the total score of TCM symptoms(P> 0.05)before medication,and they can compare with each other.After medication,the total score of TCM symptoms in both groups was significantly lower than before(P <0.05),indicating that both groups of drugs can improve the clinicalsymptoms of patients with Hp-positive chronic gastritis and spleen deficiency dampness-heat syndrome.After medication,the total score of the test group is less than the total score of the control group,the discrepancy is obvious(P <0.05),it shows that the test group has a clear advantage over the control group in reducing patient discomfort symptoms.3.Analysis of the scores of each single item of TCM symptomsBefore medication,the two groups had almost no difference in the scores of individual TCM symptoms(P> 0.05),and they can compare with each other.After medication,each single symptom score of the test group was obviously lower than before medication(P <0.05);there was no efficacious change in the scores of stomach pain,nausea and vomiting in the symptom scores of the control group,and no difference Significance in learning(P> 0.05),the score of mouth bitterness or sticky symptoms increased,there was a significant difference(P <0.05),the score of the remaining symptoms decreased significantly,there was an obvious change(P <0.05).After medication,the test group showed no obvious disparity from the control group in reducing fatigue,noisy stomach,and bad breath symptoms(P> 0.05).The scores of other single symptoms in the test group were less than those in the control group,with significant differences(P <0.05).4.Integration comparison of Pro Quality of life scaleThere was no obvious disparity in the scores of various factors and total scores between the two groups before medication(P> 0.05).Comparison between the two groups after medication,the comparison of each factor score and total score of the test group before and after treatment was significantly reduced,with a significant difference(P <0.05);the control group before and after medication,various factor scores and total score were significantly reduced,The difference was significant(P<0.05).There is almost no gap in the scores of psychological and social function factors between two groups after medication(P> 0.05).The test group had significant differences in terms of reflux,dyspepsia,abnormal bowel movements,general body condition and total score Less than the control group,with significant differences(P <0.05).5.Comparison of mental anxiety improvementBefore medication,the two groups had almost no gap in the points of anxiety(P> 0.05).Comparison within group after medication,Both groups' anxiety status scores decreased obviously(P <0.05).After medication,the test group's anxiety status score was obviously less than the control group(P <0.05).6.Hp Comparison of eradication rate and numerical changeThe values of 13 C urea breath test before medication were not obviously gap between the two groups(P> 0.05),and were comparable.Comparing the eradication rates of the two groups,the eradication rate of the test group was 21.88%;the eradication rate of the control group was 75.76%.The Hp eradication effect of the control group was obviously better than that of the test group(P <0.05).Comparison of changes in the two groups of values,the values within the two groups after medication were significantly lower than those before the treatment(P <0.05);after the treatment between the two groups,the value in the control group was significantly smaller than the value in the test group(P <0.05).Comparing the number of people with decreased Hp values between the two groups,the proportion of people in the experimental group who experienced a decrease in Hp value after treatment was 81.25%;the proportion of those who fell in the control group after treatment was 93.94%.There is almost no gap in the proportion of the two groups whose numbers have dropped(P> 0.05).7.Evaluation of adverse reactionsThrough the observation of safety indicators,the adverse reactions during the medication of the two groups are as follows:One case of nausea and retching in the test group;The control group had 2 cases of nausea and vomiting,4 cases of diarrhea,and 1 case of tongue pain.The above-mentioned patients had mild adverse reactions,did not meet the shedding standard of cases,and all improved or recovered after symptomatic treatment during the study.ConclusionHuanglian Decoction in the treatment of Hp positive chronic gastritis of spleen deficiency and damp heat type has a significant effect compared with bismuth quadruple therapy,which can obviously reduce the patient's discomfort,ameliorate the quality of life of patients,improve the state of anxiety of patients,with small side effects and high safety,but in the short term,the efficacy of eradicating Hp is not as good as bismuth quadruple therapy.If the traditional Chinese medicine Huanglian Decoction and Western medicine bismuth quadruple therapy are used simultaneously to treat the patients with Hp positive chronic gastritis of spleen deficiency and damp heat type,the overall effect may be better,which needs further study for clinical promotion. |
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