| Objective:By randomized controlled clinical trials,to observe the liver Fried sugar pill for change,hot and humid embodiment in patients with type 2 diabetes,the effect of clinical symptoms and laboratory indexes to evaluate liver Fried sugar pills for liver pixu(spleen deficient),hot and humid embodiment the clinical curative effect and safety of type 2 diabetes,and for Chinese medicine in the treatment of type 2 diabetes to provide new ideas and scientific basis.Methods: 83 patients with liver depression and spleen deficiency with damp-heat accumulation who met the inclusion criteria were randomly divided into treatment group(42 cases)and control group(41 cases).The treatment group was treated with Tangganwan on the basis of western medicine.The control group was treated with western medicine plus metformin enteric-coated tablets.The treatment cycle was 12 weeks.The clinical efficacy and safety of tanggan decoction in the treatment of type 2 diabetes were evaluated by collecting and sorting the improvement of TCM symptoms of patients in the control group and the observation group,as well as the levels of laboratory indicators such as blood glucose,glycosylated hemoglobin,insulin,homa-ir and blood lipid,and using SPSS20 statistical analysis software.Results:The basic data of age,gender and course of disease of the patients in the treatment group and the control group before treatment were compared between the two groups.There was no difference between the two groups,and the difference analysis was not statistically significant(P > 0.05),which was comparable.After 12 weeks of treatment: 1.BMI: intra-group comparison: the BMI of the two groups was lower than before,and the difference analysis results were statistically significant(P < 0.05).Intergroup comparison showed that BMI of twogroup was no difference between the two groups,and the difference analysis was not statistically significant(P > 0.05).2.TCM symptom score:both groups of patients showed improvement in TCM symptoms after treatment,with the improvement rate of 87.5% in the treatment group,and the symptom score decreased from 17.56±1.13 to 7.26± 2.36 after treatment.The total effective rate in the control group was 62.5%.The symptom score decreased from 17.02 ±1.29 to 10.53± 2.54 after treatment.The therapeutic effect of the treatment group was significant compared with the treatment group(P < 0.05).3.Blood glucose and glycosylated hemoglobin: the blood glucose(fasting and2 h after meal)and glycosylated hemoglobin of the patients in the treatment group and the control group were lower than those before treatment,and the difference analysis was statistically significant(P < 0.05).Comparison between groups: there was no significant difference between the treatment group and the radiotherapy group,and the analysis showed no statistical significance(P > 0.05).4.Insulin resistance coefficient: homa-ir was improved in both treatment group and control group after treatment,and the results were statistically significant(P < 0.05).After treatment,homa-ir of the treatment group was not significantly different from that of the control group(P > 0.05).5.Lipid level: intra-group comparison: TG,TC,ldl-c and hdl-c levels in the treatment group were improved after treatment compared with before treatment,respectively,and the results were statistically significant(P < 0.05).TC,TG,ldl-c and hdl-c levels in the control group were also improved after treatment,but the improvement was not significant compared with that before treatment(P > 0.05).Comparison between groups: after treatment,TG,TC,ldl-c and hdl-c levels in the treatment group were significantly lower than those in the control group,with statistica lly significant results(P < 0.05).6.Liver function of patients in the two groups(ALT and AST): compared wit-hin the group,ALT and AST in the treatment group and the control group we-re significantly decreased,and the results were statistically significant(P < 0.05).Compared with the control group,ALT and AST levels in the treatment g-roup decreased significantly,and the difference analysis was statistically sign-ificant(P < 0.05).Conclusion: TangGanjanwan can significantly improve the clinical symptoms of type 2 diabetes patients with liver depression and spleen deficiency,dampness and heat,reduce BMI,decrease blood glucose and glycosylated hemoglobin,improve insulin sensitivity,adjust blood lipid level,improve liver function and protect liver,and have high safety.It is suitable for clinical treatment of type 2 diabetes patients. |
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