The Academic Idea Of Professor Cao Liping&the Clinical Research Of The Efficacy Of "Jian Pi Qing Fei Tang" In Treating Nsclc

ObjectsThis paper aims at arranging the clinical experience of Professor Cao Liping as a domestic famous physician of Chinese medicine for treating Non-small-cell lung cancer(NSCLC)systematically;summarizing her therapeutic principle and medication feature;excavating and summarizing the academic experience of famous professors in traditional Chinese Medicine,refining professor Cao Liping's academic theory;and verifying the clinical effect of "Jian Pi Oing Fei Tang" for treating Non-small-cell lung cancer by clinical research to evaluate the influence of it on the patients in Traditional Chinese Medicine(TCM)Syndrome,survival time and survival quality,in order to establish Chinese medicine diagnosis and treatment program based on Professor Cao Liping's academic idea for treating Non-small-cell lung cancer.Method1.Academic Experience ResearchConcluding the clinic experience of Professor Cao Liping for treating Non-small-cell lung cancer.Pulmonary disease and internal medicine from several sources,such as experience of the author when following teacher,experience of clinic svndrome,clinic outpatient.subject discussion,consultation of difficult disease and so on.The author also looked up some relative literature,case records of Chinese medicine and the study journal over 3 years when flowing Prof.Cao.2.Clinical ResearchBy using parallel and controlled methods,the author did the clinical trial on a total of 69 patients in stage ?&? of NSCLC with spleen deficiency and pulmonary syndrome from October 2012 to October 2015 in Shaanxi Provincial Hospital of Traditional Chinese Medicine and Shaanxi Provincial Tumor Hosnital.The natients were separated two group-treatment group and contrast group,including 35 cases in treatment group for the treatment method o "Jian Pi Oing Fei Tang"combined with western medicine treatment.and 34 cases in contrast group for the treatment method of western medicine treatment.The treatment lasted 12 weeks as a course of treatment.Then the two groups of patients were evaluated obiectivelv in the status of TCM syndrome,survival aualitv,physical condition and general survival period.SPSS18.0 was used for the statistical analysis.Results1.Academic Experience Research ResultFirstly,this paper summarized professor Cao Lining's clinical experience and refines it into her academic thoughts.That is the treatment of lung disease is reflected in "the essence is to clean the lung",which means treatment of internal miscellaneous disease should start from curing the lung and use "warming bile soup"to defeat ills.Secondly,summarized the treatment characteristic of Professor Cao Liping in NSCLC.That is "asthenia in origin and illness in superficiality" is the main cause of NSCLC.Evil heat in the lung is the surface phenomenon of lung cancer,but the deficiency of "Oi" of spleen is the origin of lung cancer.The main way to cure the disease is to pay attention to cure the lung and the spleen simultaneouslv.The most important principle is to strengthen the function of spleen while eliminating lung-heat.Prof.Cao believed that the spleen deficiency,lung loses normal function of dispersing and descending,endogenous phlegm,phlegm dampness,blood stasis,blood stasis for heat after a long time.So Phlegm,dampness,blood stasis,and heat from blood stasis forms the resistance and becomes lung heat accumulation.The spleen deficiency and lung heat is one of the most common clinical syndromes,the syndrome of cough,expectoration,white or yellow sputum,or sputum with blood.accompanied by fatigue.shortness of breath,aggravating after activity.pale red tongue with white or yellow greasy fur,thready pulse or string slide.Aiming at the deficiency of spleen and lung heat syndrome,the treatment principle is strengthen the function of spleen and eliminating lung-heat.and treat the disease with "Jian Pi Oing Fei Tang".Strengthening the function of spleen is origin for treatment lung cancer,simultaneous treatment for lung and spleen is clinical specific manifestation and application of the method of "Pei Tu Sheng Jin".For the treatment of NSCLC,Professor Cao form "Jian Pi Oing Fei Tang" with years of clinical experience,the clinical effect is obvious.The decoction of "Jian Pi Oing Fei Tang" which is made from the following main herbs:Fructus aurantii,Platvcodon grandiflorum,dried tangerine peel,Rhizoma pinellinae praeparata,Poria,Scutellaria baicalensis.White mulberry root-bark,Thunberg fritillarv bulb.Prunella vulgaris,Honeysuckle stem.Fried atractvlodes.radix oseudostellariae,Fried malt,Saposhnikovia divaricata,Perilla leaf,Coix seed.Cuttlefish bone,Glvcvrrhiza uralensis fisch.The principle of "Jian Pi Oine Fei"(strengthening spleen and eliminating lung-heat)is an important treatment rule which is summarized from Professor Cao Liping for treating NSCLC,it is suitable for those patients with spleen deficiency and lung heat syndrome,and it can apply throughout.The prescription of"Jian Pi Oina Fei Tang" can be widely used for the patients with NSCLC of postoperation,chemotherapy,radiotherapy and advanced stage,and can be used for long term.In the clinical application of "Jian Pi Oing fei Tang",we should pay attention to treat the patients with differentiation therapy,and adiust medication according to the different clinical manifestations of patients.If the patient is in surgery,radiotherapy and chemotherapy.we can adjust the dose of "Jian Pi Oing Fei Tang",increase the amount of herbs of supplement qi in order to strengthen and reinforce the foundation of power:In the basis of dose adjustment for the nausea and vomiting in chemotherapy patients with,add bamboo Shavings,ginger,and iuiube,to the harmonize the stomach and check vomiting;If low white blood cell for the patients,often add Astragalus membranaceus,Glossy privet fruit,in order to tonify Oi and nourish Kidney Yin;During radiotherapy and after radiotherapy for patients with dry mouth,dry throat,add Dendrobium,reed rhizome,Lily in order to nourish Yin and moisten lung to reduce the heat radiation caused by heat injury symptoms:If the patient is in stable period and early period after surgery,radiotherapy and chemotherapy,it should be increased the dose of eliminating lung-heat,reducing phlegm and resolving masses to strengthen eliminating antineoplastic effect.For advanced and exhaustive natients.should increase the amount of tonifing qi and reinforcing power,meanwhile,reduce those dose of eliminating lung-heat,reducing ohlegm and resolving masses,that is to increase the strength and reduce the power of eliminating evil,so it can adapt to the needs of the patient.2.Clinical Research ResultTCM syndrome:TCM syndrome scores:The TCM syndrome score(before and after treatment)of treatment eroup passed the t test(t=11.086,P=0.000);The TCM syndrome score(after treatment)of both groups passed the t test(t=-2.628,P=0.011);:Both showed significant difference statisticallv(P<0.05).Among them,The TCM syndrome score of cough(before and after treatment)of treatment group passed the t test(t=11.22.P=0.004);The TCM syndrome score(after treatment)of both groups passed the t test(t=-2.66.P=0.01);Both showed significant difference statisticallv(P<0.05).The TCM syndrome score of sputum(before and after treatment)of treatment group passed the t test(t=17.92,P=0.017);The TCM syndrome score(after treatment)of both groups passed the t test(t=-3.01,P=0.004);Both showed significant difference statistically(P<0.05).The TCM syndrome score of shortness of breath(before and after treatment)of treatment group passed the t test(t=7.85,P=0.001),this showed significant difference statistically(P<0.05).The TCM syndrome score(after treatment)of both groups didn't pass the t test(t=-1.93,P=0.057),and showed no significant difference statisticallv(P>0.05).The TCM syndrome score of fatigue(before and after treatment)of treatment group passed the t test(t=9.22,P=0.026);The TCM syndrome score(after treatment)of both groups passed the t test(t=-3.96,P=0.00);Both showed significant difference statistically(P<0.05).TCM syndrome efficacy:In treatment group,the treatment was markedly effective in 7 cases,accounting for 20.00%;effective in 23 cases,accounting for 65.71%;ineffective in 5 cases,accounting for 14.29%.In contrast group,the treatment was markedly effective in 2 cases.accounting for 5.9%;effective in 19 cases,accounting for 55.88%:ineffective in 13 cases,accounting for 38.24%.The difference of the two group nassed the Chi-sauare test(x 2=6.524,P=0.038),the result showed significant difference statistically(P<0.05).Functional evaluation:The daily activity score(before and after treatment)of treatment group passed the t test(t=5.893,P=0.000);The daily activity score(after treatment)of both groups passed the t test(t=-2.082,P=0.041);Both showed significant difference statistically(P<0.05).The society and family score(before and after treatment)of treatment group didn't pass the t test(t=-1.390,P=0.173),and showed no significant difference statisticallv(P>0.05):The society and family score(after treatment)of both groups passed the t test(t=2.581,P=0.012),this showed significant difference statistically(P<0.05).The emotion score(before and after treatment)of treatment group passed the t test(t=6.509,P=0.000):The emotion score(after treatment)of both groups passed the t test(t=2.245,P=0.028);Both showed significant difference statistically(P<0.05).The activity ability score(before and after treatment)of treatment group passed the t test(t=-8.133,P=0.000),this showed significant difference statisticallv(P<0.05):The activity ability score(after treatment)of both groups didn't pass the t test(t=1.865,P=0.067),which didn't show significant difference statistically(P>0.05).The additional attention score(before and after treatment)of treatment group passed the t test(t=5.822,P=0.000),this showed significant difference statisticallv(P<0.05):The additional attention score(after treatment)of both groups didn't pass the t test(t=-0.515,P=0.609),which didn't show significant difference statistically(P>0.05).Body strength:Kamofsky perform status:In treatment group,the Carr's score was raised in 27 cases.accounting for 77.14%;stable in 6 cases.accounting for 17.14%;declined in 2 cases,accountine for 5.72%.In contrast group,the Carr's score was raised in 18 cases,accounting for 52.94%;stable in 7 cases.accounting for 20.59%:declined in 9 cases.accounting for 26.47%.The difference of the two group passed the Chi-square test(x2=6.257,P=0.042),the result showed significant difference statistically(P<0.05).Body weight:In treatment group,the weight was raised in 23 cases,accounting for 65.71%;stable in 7 cases,accounting for 20%;declined in 5 cases,accounting for 14.29%.In contrast group,the weight was raised in 19 cases,accounting for 55.88%;stable in 5 cases,accounting for 14.71%:declined in 10 cases.accounting for 29.41%.The difference of the two group didn't pass the Chi-square test(x 2=2.333,P=0.305),the result showed no significant difference statistically(P>0.05).Survival time:Progression-free survival:The progression-free survival time(after treatment)of both groups passed the t test(t=-4.892,P=0.033),the result showed significant difference statistically(P<0.05).No toxic reaction and side effect was found in the whole study.Conclusions1.By combing Professor Cao Liping's clinical experience,the article summed up Professor Cao Liping's academic concept in treating lung diseases,tumor and medical diseases concept,summed up the treatment rules and characteristics of prescription medication,and presented that strenegthening spleen and eliminating lung-heat is an imoortant principle for the treatment of NSCLC."Jian Pi Qing Fei Tang"should be used for the treatment.2.The clinical study of Jian Pi Oing Fei Tang for treating NSCLC showed that the treatment group can obviously reduce the patient's cough,expectoration,shortness of breath and other symptoms,the patient's daily activity,emotion and activity ability were improved,Karnofskv perform status was raised,and survival time was prolonged,thus,the treatment can significantly improve the quality of life and prolong the survival time of patients in treatment grouo Jian Pi Oing Fei Tang accompanied with the basis treatment of Western medicine in the treatment of NSCLC is superior to simple treatment of western medicine,and is safe and effective.This study refines the academic thoughts of Professor Cao Liping,the characteristics of treatment for NSCLC,and the medication regularity of "Jian Pi Oing Fei Tang".Meanwhile,it choose the functional assessment of cancer therapy-lung to analyze and evaluate the clinical efficacy of the treatment plan,thus verified the effectiveness of "Jian Pi Oing Fei Tang" in treating lung cancer.Explained finally that the prescription of "Jian Pi Oing Fei Tang" from years of clinical practice suits clinical actuality and changing regularity of pathogenesis of NSCLC,the "Jian Pi Oing Fei Tang" is effective prescription for treating NSCLC,and it is worthy of further study and clinical promotion.The study provided an new thought for clinical treatment of NSCLC,it offer an reference and support for further exploring the treatment plan which contains maintain and treat for the advanced lung cancer with Chinese medicine,excavating the academic connotation of famous traditional Chinese Medicine.