The Clinical Observation Of Modified Wumei Wan Decoction In The Treatment Of Diarrhea Type Irritable Bowel Syndrome(cold-heat Complicated Syndrome)

Objective: By comparing the clinical efficacy of traditional Chinese medicine modified Wumei Wan and Guchang Zhixie Wan in the treatment of diarrhea type irritable bowel syndrome(cold-heat complicated syndrome),the evaluation of the clinical effectiveness and security of the treatment of diarrhea irritable bowel syndrome by the classical prescription of TCM was achieved.Furthermore,it proves the superiority of syndrome differentiation based on the holistic concept of TCM in disease remission and symptom improvement,ultimately,this study provides the evidence for TCM treatment of diarrhea type irritable bowel syndrome(cold-heat complicated syndrome)in the future.Methods: All the 72 patients in this study were the outpatient in the hospital affiliated to Changchun University of Traditional Chinese medicine,and all were patients with diarrhea type irritable bowel syndrome(cold mixed certificate).A randomized controlled method was used to randomly divide the selected cases into 2 groups,36 cases in the treatment group and 36 cases in the control group.Give the treatment group modified Wumei Wan Chinese medicine decoction,water fried juice 300 ml,each 150 ml,morning and evening after meals oral;meanwhile Give the control group Guchang Zhixie Wan,each 5g,3 times a day after meals oral,take 28 consecutive days for 1 courses,observe 1 courses.Two groups of patients recorded TCM symptom integral,IBS-SSS scale before and after the treatment,and applied statistical treatment analysis to estimate its therapeutic effectiveness.Following up for 1 months,observe the recurrence,all the patients before and after the treatment were required to test electrocardiogram and other safety observations to assess safety.Results: A total of 60 patients completed the study according to the treatment plan,30 cases in the treatment group and 30 cases in the control group.Comparing the total efficiency of the two groups: The rate value of the treatment group was96.7%,of which 14 cases were healed,13 cases were effective,2 cases were valid,1 cases were ineffective,and the total effective rate of the control group was 93.3%,of which 7 cases were healed,15 cases were effective,6 case were valid,2 cases were ineffective.and by Ridit analysing,P<0.005,which meant the treatment group was dramatically more effective than the control group.Comparing the symptom points of two groups: the total integral average of the treatment group were 17.80±4.80 and 2.07±2.72 before and after therapy,and the average of the control group before and after therapy were 17.17±3.74,4.77±4.22,through statistical testing,there was no obvious difference in the untreated total points between the two groups(P>0.05),and there were obvious differences in the total points of posttreatment between the two groups(P<0.01),which indicated that the treatment group made symptoms better improved.Compariing improvement of each symptom between the two groups:statistical tests showed an improvement in symptoms(P<0.05)after treatment in two groups,and patients of group have responded more significanttly to the treatment(P<0.05),and there was no difference between the two groups in the improvement of abdominal pain and diarrhea symptoms(P > 0.05),while the treatment group had better improvement of abdominal distension,borborygmus,mouth-bitterness and chills(P<0.05).IBS-SSS scores comparison between two groups:the untreated scores between two groups were no statistical differences(P > 0.05),but the average score after treatment was 49.17±51.06,95.00±57.76,which meant a apparent difference(P<0.01),and it proved the alleviation of severity of disease in the treatment group was more evident.There were no adverse reactions neither in the treatment group,nor control group.Conclusion: With the principles of calming cold and heat,soothing liver and regulating spleen,we should pay attention to the regulation of five zang-organs functions,Qi and emotion.Treating the diarrhea type irritable bowel syndrome(cold mixed syndrome)with modified Wumei Wan Chinese medicine decoction which has been proved safer can better improve the main clinical symptoms and quality of life,regulating emotion,also no adverse reactions.