Clinical Observation Of The Method Of Pingtiao Hanre Combined With Western Drugs To Treat The Intermingling Of Cold And Heat Pathological Basis Of Overlap Syndrome In Gastro-esophageal Reflux Disease And Diarrhea—Predominant Irritable Bowel Syndrome

Background:Being two types of common digestive system diseases,Gastro-esophageal Reflux Disease(GERD)overlapping Irritable Bowel Syndrome(IBS)is not rare.With the changing of people' s life style and dietary structure,the incidence of the overlap syndrome in GERD and IBS is rising,attacking patient's quality of life.Objective:This study aimed to investigate the clinical effect of the method of Pingtiao Hanre combined with western drugs in treating the overlap syndrome in GERD and IBS-D(cold and heat mixed type).Methods:The 60 patients of GERD overlapping IBS-D(cold and heat mixed type)were divided into 2 groups by randomly.There were 30 cases in the control group and 30 cases in the treatment group.All patients of the control group were treated with Rabeprazole combined with live combined bacillus subtilis and enterococcus faecium enteric-coated capsules.The recipe of the other 30 patients of the treatment group traditional Chinese medicine for Pingtiao Hanre combined with routine western medicine the same as the recipe of the control group.The treatment period of all the cases is 8 weeks.The severity score of irritable bowel severity scoring system(IBS-SSS),the reflux disease questionnaire(RDQ),and the traditional Chinese medical symptoms score is used to evaluated the symptoms of pretreatment and post treatment of each group,then effects of the treatments is evaluated by both RDQ and IBS-SSS.Both the total score of traditional Chinese medical symptoms and each entry of seven main TCM symptoms is observed for thorough evaluation.Data was analyzed by SPSS 22.0 statistical software.Results:1.Comparison of the total score of RDQ in the treatment group and the control group:for both treatment group and control group,the total score at post-treatment is lower than that at prior-treatment(P<0.05).25 cases in the treatment group got RDQ score less than 12,while there were only 16 cases in the control group.The difference between the two groups was significant(P<0.05),illustrating curative effect of GERD in treatment group was significantly better than that in control group.2.Comparison of RDQ grade improvement of treatment and control groups:the total RDQ grade improvement of the treatment group was 96.6%,while that of the control group was 73.3%,the difference between the two groups was significant(P<0.05),illustrating the curative effect of RDQ grade in treatment group was significantly better than that in the control group.3.Comparison of the total score of IBS-SSS in two groups:for both treatment group and control group,the total score at post-treatment is lower than that at pre-treatment(P<0.05).The post-treatment scores in treatment group(128.50±44.89)were significantly lower than those in control group(179.33±57.32)(P<0.05).4.Comparison of IBS-SSS therapeutic level of two groups:the total effective power of the treatment group(90.0%)was higher that of the control group(66.6%),the difference between the two groups was significant(P<0.05).5.Comparison of total score of the TCM symptoms in two groups after treatment:both groups could reduce the TCM symptoms integral post-treatment(P<0.05);the total TCM symptoms score of the treatment group is 14.40±4.43,and comparing with the control group(21.43±4.98)there is a significant difference(P<0.05).6.Comparison of each entry of seven main TCM symptoms score in two groups:both groups could reduce each entry of seven main symptom score post-treatment(P<0.05).There were significant differences between two groups in terms of heart burn sensation,diarrhea frequency,stomachache due to cold and empty stomach,abdominal pain before defecation(P<0.05),the score of the treatment group was lower than that of the control group.But in the term of acid regurgitation and mucus or jelly in the feces,there were no significant differences(P>0.05).7.Comparison of total score of the secondary TCM symptoms in two groups after treatment:both groups could reduce the secondary TCM symptoms integral post-treatment(P<0.05);the total secondary TCM symptoms score of the treatment group(6.20±2.92)was lower than that of the control group(8.50±2.54)(P<0.05)Conclusion:The efficacy of the method of Pingtiao Hanre combined with western drugs in treating the overlap syndrome in GERD and IBS-D(cold and heat mixed type)was remarkable.this method could significantly ameliorate the complicated clinical syndromes,and improve patient's quality of life.