| Background Several studies have suggested that the quality of semen is declined in the last few decades,which have aroused wide attention.Studies have shown that inflammation is a key risk factor for semen quality.Reproductive system infection and inflammatory reaction can lead to the deterioration of semen quality.Previous studies have reported diet plays a role in regulating chronic low-grade inflammation.Different dietary components or nutrients have different effects on inflammatory cytokines,some of which have anti-inflammatory effects,some of which have pro-inflammatory effects,and the degrees of influence is different.However,evidence is lacking on whether the inflammatory potential of diet can impact semen quality.Dietary Inflammatory Index(DII)is a new tool to assess the overall inflammatory potential of the diet.Accordingly,Therefore,the study used DII as a new tool to explore the relationship between dietary pro-inflammatory/anti-inflammatory effect and semen quality.In order to provide evidence for nutritional education and dietary intervention for men in the future.Objective The purpose of the study was to use the new tool for evaluating dietary quality comprehensively and comprehensively,to explore the correlation between dietary pro-inflammatory/anti-inflammatory effects and the quality of male semen in reproductive clinics.In order to provide evidence for nutritional education and dietary intervention for men in the future.Methods In the study,Male patients were selected from the outpatient department of the reproductive center of a hospital in Hefei from 2016 to 2017.General information such as age,education,per capita family income,occupation and lifestyle were investigated by general information questionnaire.A previously validated food frequency questionnaire(FFQ)was used to collect the frequency and the average amount of food consumed each time over the past year,and DII was calculated to evaluate dietary quality.Semen parameters such as sperm concentration,sperm motility and sperm morphology were analyzed and detected by computer aided analysis system(CASA).Semen quality was evaluated according to World Health Organization reference values2010 guidelines.Groups according to the total score of the DII tertiles.The total sperm count,sperm concentration,progressive motility,total progressive motility,and sperm morphology were qualified as the dependent variable.DII as independent variable for multiple logistic regression analysis,explore the risk factors of semen quality parameters,after adjusting for possible potential confounding factors.Results A total of 213 men aged 21-43 years old were involved in the study.The mean age of the study participants was 30.2±4.5 years.The abnormal rate of semen quality was 54.93%.Analysis of factors affecting semen quality showed that subjects with BMI in the normal range had higher semen volume levels(3.5±1.5 vs 3.2±1.4,p<0.05).Compared with inactive exercisers,men with regular physical activity had higher sperm concentration(79.5±75.0×10~6/ml vs 59.5±64.5×10~6/ml)and lower abnormal sperm morphology rate(94.5±2.5%vs 95.3±2.3%).Semen quality parameters were analysis according to DII tertile.Compared to men in the lowest tertile of the dietary inflammatory index,the men in the highest tertile of DII exhibited poor semen quality for total sperm count(271.2±274.6 vs 177.6±202.3),total progressive motility(61.6±21.6 vs 53.0±21.0),sperm morphology(93.7±8.8 vs 95.6±2.4),and sperm volume(3.8±1.7 vs 3.0±1.2)(p<0.05).After additional adjusting for possible co-variables,multiple logistic regression analysis showed that DII was a risk factor for progressive motility.(OR=2.80,95%CI:1.33-5.77,p=0.011).In addition,DII increased the risk of abnormal sperm morphology(OR=3.48,95%CI:1.60-7.81,p=0.005).Conclusion The results show that DII was correlated with semen quality:(1)DII tertile was associated with poor semen quality compared to the lowest DII tertile among men.such as total sperm count,total sperm motility,sperm morphology and semen volume.(2)DII can increase the risk of abnormal progressive motility and abnormal morphology.Men can improve semen quality by improving their diet during reproductive years. |
