| OBJECTIVE:In this study,the self-prepared prescription "Shunqi Jieyu Decoction" was used to treat patients with liver-qi stagnation after depression and mild-ischemic stroke.Compared with the western medicine group,the degree of depression,sleep quality and neurological deficit were compared before and after treatment.The improvement of TCM syndromes of liver qi stagnation and the comparison of the scores of various scales,etc.,and whether the self-prepared prescription "Shunqi Jieyu Decoction" can benefit patients with mild to moderate ischemic stroke and depression,and is treated by Chinese medicine.Post-ischemic post-stroke depression provides new ideas for diagnosis and treatment.Methods:Sixty patients with mild-to-moderate ischemic post-stroke depression and liver qi stagnation were collected.All cases were from outpatients and inpatient departments of the Encephalopathy Center of Jiangsu Provincial Hospital of Traditional Chinese Medicine.They were randomly divided into a test group and a control group,each group consisting of 30 people.Both groups of patients were routinely treated with ischemic stroke(control blood pressure,blood sugar,blood lipids,anti-platelet aggregation,nutritional brain function,etc.).The experimental group was given Shunqi Jieyu Decoction(the drug composition was Tianma 10g,Xiangfu 10g,Baizhi 10g,Chuanxiong 10g,Qingpi 10g,Shenshaishen15g,Shanzhizi 10g,Wuyao 6g,Cangzhu 10g,Jiao10g,Jiaoliuqu 10g,Chaobaishu 10g,Zhigancao 6g,Zisu10g,Mugua 10g),1 day,Shuijian,morning and evening service.The control group was given flupentixol melitracene(Danish Lingbei Pharmaceutical Co.,Ltd.).The course of treatment was 8 weeks,and no other related antidepressant or antipsychotic drugs were given during the test period.Observation methods:1 observation and comparison of the two groups of general data(gender,age)2 observation and comparison between the two groups of HAMD(Hamilton Depression Scale),CSS(Clinical Neurological Deficit Rating Scale 1995),PSQI(Pittsburgh Sleep Index Number Table And the changes in the scores before and after treatment of the TCM symptom score scale.3 observation and comparison of two groups of safety indicators.The relevant data were processed by SPSS 23.0 software for statistical analysis.Results:(1)Comparison of depression improvement:The total effective rate of the experimental group was 86.67%,and the total effective rate of the control group was 76.67%.After treatment,the HAMD scores of the experimental group and the control group were lower than those before treatment,and the difference was statistically significant(p<0.05).There was no significant difference in the HMAD scores between the two groups before treatment(p>0.05),which was comparable.There was no significant difference in HAMD scores between the two groups after treatment(p>0.05),indicating that the test group and the control group were equally effective in improving depression.(2)Improvement of neurological deficit:The total effective rate of the experimental group was 80%,and the total effective rate of the control group was 63.33%.The CSS scores of the two groups were lower than those before treatment,and the difference was statistically significant(p<0.05).There was no significant difference in the pre-treatment CSS scores between the two groups(p>0.05),which was comparable.After treatment,the CSS scores of the experimental group and the control group were significantly different(p>0.05),indicating that the experimental group was better than the control group in restoring the recovery of neurological deficits after ischemic stroke.(3)Improvement of sleep disorders:the total effective rate was 77.78%in the experimental group and 40%in the control group.The PSQI scores in the two groups were lower than those before treatment(p<0.05).There was no significant difference in the PSQI scores between the two groups before treatment(p>0.05),which was comparable.After treatment,the PSQI scores of the experimental group and the control group were significantly different(p>0.05),indicating that the experimental group was better than the control group in improving the sleep of patients with post-ischemic stroke.(4)Improvement of TCM symptom:The total effective rate of the experimental group was 86.67%,and that of the control group was 53.33%.The TCM scores of the experimental group and the control group decreased after treatment,and the difference was statistically significant(p<0.05)..There was no significant difference in the scores of the pre-treatment symptom scores between the two groups(p>0.05),which was comparable.After treatment,the scores of TCM syndrome scores in the two groups were statistically significant(p>0.05),indicating that the experimental group was better than the control group in improving TCM symptoms in patients with post-ischemic stroke.(5)Before treatment,the test group had no significant difference(p>0.05)in the six syndromes of emotional depression,grievance,goodness,insomnia,suffocation,and restlessness(p>0.05),which was comparable.After treatment,the test group had significant difference(p<0.05)after comparing the above six syndrome scores with the control group,indicating that the test group was better than the control group in improving the above six syndromes.(6)Before treatment,there was no significant difference(p>0.05)between the three syndromes of chest fullness,forgetfulness and irritable irritability in the experimental group(p>0.05).After treatment,there was no significant difference between the above three syndromes and the control group(p>0.05),indicating that the test group and the control group improved the symptoms of chest fullness,forgetfulness,irritability and irritability.Poor.(4)Adverse event analysis:There was no significant difference in blood routine,liver and kidney function,coagulation function and electrocardiogram before and after treatment.One patient developed transient bloating during the test group.In the control group,2 patients developed palpitation and 1 patient developed mild dizziness.Symptoms disappeared by themselves within 1 week of taking the drug.Conclusion:Shunqi Jieyu Decoction can reduce the degree of depression in patients with liver-qi stagnation after depression and mild-ischemic stroke,promote the recovery of neurological function,improve sleep,improve TCM symptoms and medicinal safety,and have fewer adverse reactions.Clinical treatment of post-ischemic post-stroke depression has reference value. |
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