Meta-analysis Of Several Factors Related To Peri-implantitis

Objective:The aim of this study was to conduct a qualitative analysis on the risk factors of peri-implantitis by using the Meta analysis method.The correlation between chronic periodontitis,type 2 diabetes mellitus smoking and the occurrence of peri-implantitis was mainly analyzed here.Methods:According to the established search strategy and search terms,search for EMbase,Pubmed,The Cochrane Library,ISI Wed of Knowledge,China Knowledge Network Database,China Biomedical Database,Wanfang Database,Weipu Database and Planting Related Chinese and English Journals The article on the association between peri-implantitis and chronic periodontitis,type 2 diabetes mellitus and smoking,the deadline is September 2018.According to the strict inclusion exclusion criteria,the retrieved literature was screened,the full text was used to obtain the required data and research information,and the quality of the study was evaluated by the NOS scale.The relative risk RR and the 95% confidence interval were selected as the effect size.And the corresponding effect model was selected according to the results of heterogeneity analysis.Statistical analysis of the resulting data was performed by Review Manager 5.3 software,and the effect model was changed and the small sample study was removed for sensitivity testing to determine the stability of the final results.The results were interpreted by a Forest Plot and the funnel plot was used to assess publication bias.Results:A total of 33 related studies,including 28575 implants,were included in the final analysis.(1)The chronic periodontitis group included 18 studies with 13823 implants,the combined effect of RR = 1.65,95% CI(1.37 1.99).Subgroup analysis was performed according to whether periodontal improvement was performed and showed that the group without effective periodontal treatment included 5 studies with 600 implants,the combined effect of RR = 1.50,95% CI(1.23-1.82),it suggests that thorough treatment of chronic periodontitis is a moderate risk factor for peri-implantitis.The group with effective periodontal treatment included 13 studies with 6,549 implants,the combined effect of RR = 3.52,95% CI(1.95-6.36),it suggests that chronic periodontitis without thorough treatment is a strong risk factor for peri-implantitis.(2)A total of 8 studies with 13,459 implants were included in the type 2 diabetes group,the combined effect of RR =1.79,95%CI(1.41-2.26).Subgroup analysis was carried out according to the effective control of blood glucose.In the blood glucose control group,there were 2 studies with a total of 711 implants,and the combined effect of RR=1.64,95%CI(1.28-2.26),it suggests that type 2 diabetes with effective control of blood glucose is a moderate risk factor for peri-implantitis;in the non-effective control group,there were 6 studies with a total of 12748 implants,and the combined effect of RR=4.40,95%CI(1.88-10.29),it suggests that type 2 diabetes without effective control of blood glucose is a strong risk factor for peri-implantitis.(3)The smoking group had 7 studies with 1,293 implants,the combined effect of RR =2.40,95% CI(1.40-4.10),Subgroup analysis was performed according to smoking cessation.The group that did not quit had 5 studies with 570 implants,the combined effect of RR = 2.30,95%(1.12-4.71),it suggests that smoking is a moderate risk factor for peri-implantitis;quit smoking group have 2 study,723 implants,the combined effect of RR = 0.80,95% CI(0.25-2.61)and 95% CI contains invalid line,indicate that quitting smoking group and control group around the implant infection risk have no difference.Conclusion:(1)Patients with chronic periodontitis without complete periodontal treatment have a strong risk of peri-implantitis,while patients with chronic periodontitis with complete periodontal treatment have an moderate risk of peri-implantitis.(2)?diabetes patients with uncontroled blood sugar have a strong risk of peri-implantitis,?diabetes patients with controled blood sugar have an moderate risk of peri-implantitis.(3)Smoking patients have an moderate risk of peri-implantitis,and those who quit smoking have no difference in the risk of peri-implantitis compared with the general population.