| Background: Bronchial asthma is a chronic airway inflammation that affects the physical and mental health of more than 300 million people around the world and places a heavy medical burden.The incidence of the disease is related to a variety of complex factors,in children with more atopic physique,some children with asthma combined with AR.Studies have shown that AR in children is an independent risk factor for childhood asthma and even prolonged to adult asthma,and it also increases the probability of recurrence of asthma after childhood[3].At present,there are few studies on the relationship between AR and asthma at home and abro ad,and there is no comprehensive and systematic study to clarify the relationship between the two.In the treatment of asthma patients,the GINA guidelines point out that asthma assessment is an important part of asthma management.At present,there are many evaluation methods for asthma control in the world,which has become a hot spot in clinical research.However,there is no unified evaluation method as a clinical application guideline,and the evaluation method is affected by many factors and people have insufficient understanding of various aspects of asthma.The application is not extensive,and further comprehensive and systematic research is needed to confirm its effectiveness.Objectives: By analyzing the pulmonary function,exhaled NO and C-ACT of 60 children with asthma,including 33 children with asthma,and 27 children with asthma and allergic rhinitis,to evaluate the changes of various related indicators after systemic treatment,and to compare the differences between pulmonary function,exhaled NO and C-ACT between the simple asthma group and the asthmatic rhinitis group before and after treatment.To conduct a correlation study between asthma assessment test and pulmonary function and exhaled nitric oxide-related indicators,to provide a reference for better assessment of asthma control.Methods : 60 children with bronchial asthma diagnosed and standardized treatment in the First Hospital of Jilin University from September 20 to 2019,including 31 males and 29 females,with an average age of(8.43±2.08)years,all patients were selected.The children were divided into simple asthma group(n=33): mean age(8.68±2.91);asthma group with allergic rhinitis(n=27): mean age(7.8±2.69)years.Observed pulmonary function related indicators(FVC,FEV1,FEV1/FVC,PEF,FEF25~75%)exhaled NO levels(including Fe NO,NNO)before treatment,3 months after treatment,and 6 months after treatment.And C-ACT score changes,while comparing the two groups of indicators,and to explore the correlation between children's asthma control test and pulmonary function,exhaled NO levels.Results:(1)Before treatment,the FVC,FEV1,FEV1/FVC,PEF,and FEF 25~75% of the asthma group were 75.33±24.21,78.27±25.28,80.53±15.16,71.24±20.73,69.52± 23.97,66.72±25.02,66.27±31.11,C-ACT score was 17.18±2.58,Fe NO was 36.03± 19.66,NNO was 443.3±247.95;FVC,FEV1,FEV1/FVC,PEF,FEF25~75% in children with asthma and allergic rhinitis.were 72.99±20.84,75.82±20.86,76.37± 17.03,65.05±20.1,64.86±2.12,65.16±22.00,63.46±20.54,C-ACT score was 16.81± 1.33,Fe NO was 49.22±45.81,NNO was 494.67±222.24;before treatment The correlation coefficients r of C-ACT scores with FVC,FEV1,FEV1/FVC,PEF,FEF25~75%,Fe NO and NNO were-0.072,0.141,0.270,0.081,0.303,0.263,0.299,-0.397 and-0.122,respectively.The corresponding P values are 0.722,0.493,0.039,0.688,0.124,0.185,0.130,0.040,and 0.569,respectively.The C-ACT score was correlated with FEV1/FVC and Fe NO at the beginning of the disease,which was positively correlated with FEV1/FVC,negatively correlated with Fe NO,and statistically significant(P<0.05).The remaining indicators were not correlated (P>0.05).(2)3 months after treatment,the FVC,FEV1,FEV1/FVC,PEF,and FEF 25~75% of the asthma group were 85.01±20.69,89.11±19.96,91.06±6,86.04±20.92,87.36±20.57,respectively.82.84±22.89,75.38±28.01,C-ACT score was 21.97±2.2,Fe NO was 27.66±19.01,NNO was 333.18±224.25;FVC,FEV1,FEV1/FVC,PEF,FEF25~75% of children with asthma and allergic rhinitis group They were 89.79±18.18,94.69±19.11,87.49 ± 9.62,87.63±19.26,89.3±21.57,88.05±20.11,84.65±25.73,C-ACT score 21.15±2.48,Fe NO 34.11±25.86,NNO 401.41±201.0.The correlation coefficient between C-ACT score and FVC,FEV1,FEV1/FVC,PEF,FEF25~75%,Fe NO and NNO at 3 months after treatment were 0.099,0.114,-0.016,0.038,0.018,0.037,-0.039,respectively.0.100 and-0.317,the corresponding P values were 0.637,0.586,0.908,0.858,0.933,0.862,0.852,0.628 and 0.155,respectively,and there was no significant correlation(P>0.05).(3)6 months after treatment,the FVC,FEV1,FEV1/FVC,PEF,and FEF 25~75% of the asthma group were 95.53±13.34,95.66±20.65,101.4±6.56,98.43±17.65,95.97±20.42,87.9±20.55,83.94±25.72,C-ACT score was 23.94±0.97,Fe NO was 24.61±12.1,NNO was 334.58±290.52;FVC,FEV1,FEV1/FVC,PEF,FEF25~75% of children with asthma and allergic rhinitis group They were 97.96±13.64,104.06±11.94,101.38±5.86,98.27±17.52,97.42±17.24,96.45±14.07,88.53±19.43,C-ACT score was 23.93±0.96,Fe NO was 24.3±11.04,and NNO was 338.07±162.43.The correlation coefficient r of C-ACT score with FVC,FEV1,FEV1/FVC,PEF,FEF25~75%,Fe NO and NNO at 6 months after treatment were-0.087,0.025,-0.010,0.019,0.260,0.412,0.603,respectively.The P values corresponding to 0.162 and 0.025 were 0.666,0.900,0.942,0.924,0.190,0.033,0.001,0.421,and 0.852,respectively.There was a positive correlation between C-ACT score and FEF50 % and FEF75% at 6 months after treatment,which was statistically significant(P<0.05).There was no significant difference in the remaining items(P>0.05).Conclusions:(1)The pulmonary ventilation function,exhaled NO and C-ACT scores of children with asthma and asthma were similar,and the control level after anti-AR and asthma treatment could achieve the same improvement.(2)Combined pulmonary ventilation function,Fe NO and C-ACT scores can be used to assess the disease control of children with asthma more comprehensively and objectively.(3)The level of NNO in children with asthma complicated with AR was significantly increased,and it was significantly improved by standardized treatment,suggesting that NNO has certain clinical reference value for the diagnosis and evaluation of nasal inflammation. |
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