The Difference Between COPD And The Asthma–chronic Obstructive Pulmonary Disease Overlap Syndrome In Exhaled Nitricoxide And Pulmonary Function

Objective:To study the difference between exhaled nitric oxide(NO)and and pulmonary function in chronic obstructive pulmonary disease(COPD)and asthma and chronic obstructive pulmonary disease(COPD)overlap syndrome(ACOS)patients for taking a beteer measurement for the diagnosis ACOS from COPD.Methods:50 patients with ACOS were classified as ACOS group from 2016 to 2017,while the 50 patients with CO PD and non asthma were classified as pure COPD group in the same period.The items of each case we collected included age,sex,smoking history.All subjects underwent pulmonary function tests,including bronchial dilation test,analysis of exhaled NO.Results:(1)The levels of age for group of asthma and COPD overlap syndrome were no significant than group of COPD(P>0.05),(2)Smokers were no significan in the group of COPD than the group of asthma and COPD overlap syndrome(P >0.05).(4)Exhaled NO detection counts were significantly higher in ACOS groups than those in pure COPD group(P<0.05).(4)Taking 45 ppb as cut-off value of FENO,the increased rate of FENO(?45ppb)in the ACOS group(88.0%)was significantly higher than that in the COPD group(10%)(P<0.01).(5)The leve ls of FVC ?FEV1/FVC? FEVl%pred for group of ACOS were no significant than group of COPD(P >0.05).Conclusion: 1.Exhaled NO detection counts were significantly higher in ACOS groups than those in pure COPD group.WhenTaking 45 ppb as cut-off value of FENO,the increased rate of FENO(?45ppb)in the ACOS group(88.0%)was significantly higher than that in the COPD group.It was valuable that it was used for early screening of ACOS in patients with COPD.2.The levels of FVC ?FEV1/FVC? FEVl%pred for group of ACOS were no significantthan group of COPD.It was little valuable that it was used for early screening of ACOS in patients with COPD.