| ObjectiveTo investigate the effect of ezopiclone and Shugan Jieyu capsule on antihypertensive effect of patients with grade 2 essential hypertension with insomnia.Method180 patients with grade 2 essential hypertension with insomnia(PSQI>7)who were admitted to our hospital from November 2017 to May 2018 were randomly divided into three groups:control group,experiment group 1,and experiment group 2.Different drug interventions were given,and the control group was given oral amlodipine besylate and valsartan;the experimental group 1 was given oral amlodipine besylate,valsartan and ezopiclone;the experimental group 2 was orally administered with benzalkonium chloride.Diping,valsartan and Shugan Jieyu capsules.Blood pressure levels(24-hour mean systolic blood pressure and 24-hour mean diastolic blood pressure),Pittsburgh sleep quality score(PSQI),anxiety self-rating scale(SAS),and depression self-rating scale were compared between the three groups before and after treatment.Scoring(SDS)and other situations.Result1.Comparison of baseline characteristics before treatment in three groups of patients Through statistical analysis,it was found that the gender,age,and body mass index of the three groups before treatment were type 2 diabetes,whether there was hyperlipidemia,smoking,systolic blood pressure(SBP)level,and diastolic blood pressure(There were no significant differences in the diastolic blood pressure(DBP)level,PSQI score,SAS score,SDS score and other indicators(P>0.05).2.Changes in the indexes of the three groups of patients before treatment and after 4 weeks of treatment and comparison of curative effects(1)Control group:ADASBP(pre-treatment:162.17±9.23,mmHg;treatment for 4 weeks:139.61±8.85,mmHg),ADADBP(pre-treatment:98.73±7.52,mmHg;treatment for 4 weeks:89.45±8.19,mmHg),PSQI(pre-treatment:16.13±1.79;treatment for 4 weeks:13.21±1.92),SAS(pre-treatment:65.11±6.27;treatment for 4 weeks:61.99±5.81),SDS(pre-treatment:62.43±5.47;treatment for 4 weeks:58.99)±4.85),ADASBP,ADADBP,PSQI,SAS,SDS were significantly decreased after treatment for 4 weeks in the control group,and the difference was statistically significant(P<0.05).(2)Experimental group 1:ADASBP(pre-treatment:161.93±8.99,mmHg;treatment for 4 weeks:127.29±8.74,mmHg),ADADBP(pre-treatment:98.59±7.27,mmHg;treatment for 4 weeks:80.37±8.39,mmHg),PSQI(pre-treatment:15.97±2.01;treatment for 4 weeks:10.23±1.46),SAS(pre-treatment:65.72±5.83;treatment for 4 weeks:54.49±6.17),SDS(pre-treatment:63.18±4.91;treatment for 4 weeks:53.77±5.51),after analysis,after the 4 weeks of treatment,the indexes of the experimental group 1 were significantly lower than those before the treatment,and the difference was statistically significant(P<0.05).(3)Experimental group 2:ADASBP(pre-treatment:162.25±8.53,mmHg;treatment 4 weeks:128.07±8.46,mmHg),ADADBP(pre-treatment:97.99±7.93,mmHg;treatment 4 weeks:81.94±7.78,mmHg),PSQI(pre-treatment:16.28±1.98;treatment 4 weeks:11.05±1.83),SAS(pre-treatment:66.20±6.79;treatment 4 weeks:56.03±5.25),SDS(pre-treatment:62.65±4.41;treatment for 4 weeks:55.03±5.06),after analysis,after the 4 weeks of treatment,the indexes of the experimental group 2 were significantly lower than those before treatment,and the difference was statistically significant(P<0.05).(4)Comparison between the experimental group 1 and the control group:ADASBP:4 weeks of treatment(experiment 1 group:127.29±8.74,mmHg;control group:139.61±8.85,mmHg),the experimental group 1 was significantly lower than the control group(P<0.05).),decreased by about 8.8%;ADADBP:4 weeks of treatment(experiment 1 group:80.37±8.39,mmHg;control group:89.45±8.19,mmHg),the experimental group 1 decreased significantly compared with the control group(P<0.05),decreased by about 10.2.%;PSQI:4 weeks of treatment(experiment 1 group:10.23±1.46;control group:13.21±1.92),the experimental group 1 decreased significantly compared with the control group(P<0.05),decreased by about 22.6%;SAS:treatment for 4 weeks(experiment Group 1:54.49±6.17;control group:61.99±5.81)The experimental group 1 decreased significantly compared with the control group(P<0.05),decreased by about 12.1%;SDS:treated for 4 weeks(experiment 1 group:53.77±5.51;control group:58.99±4.85)The experimental group 1 decreased significantly compared with the control group(P<0.05),and decreased by about 8.9%.(5)Comparison between the experimental group 2 and the control group:ADASBP:4 weeks of treatment(experiment 2:128.07±8.46,mmHg;control group:139.61±8.85,mmHg),the experimental group 2 decreased significantly compared with the control group(P<0.05).,decreased by about 8.3%;ADADBP:treatment for 4 weeks(experiment 2:81.94±7.78,mmHg;control group:89.45±8.19,mmHg),the experimental group 2 decreased significantly compared with the control group(P<0.05),a decrease of about 9.5%PSQI:4 weeks of treatment(experiment 2:11.05±1.83;control group:13.21±1.92),the experimental group 2 decreased significantly compared with the control group(P<0.05),decreased by about 16.4%;SAS:treatment for 4 weeks(experiment 2 Group:56.03±5.25;control group:61.99±5.81),the experimental group 2 decreased significantly compared with the control group(P<0.05),decreased by about 9.6%;SDS:treatment for 4 weeks(experiment 2 group:55.03±5.06;control group:58.99±4.85),the experimental group 2 decreased significantly compared with the control group(P<0.05),a decrease of about 6.7%.(6)Compared with the experimental group 2,the experimental group 1 and the ADASBP,ADADBP,PSQI,SAS,SDS and other indicators did not form statistical differences after 4 weeks of treatment.Conclusions1.Patients with grade 2 essential hypertension with insomnia and PSQI score>7 points orally administered amlodipine besylate,the antihypertensive effect of saponin was exact,and after 30 days of antihypertensive treatment,the sleep quality of the three groups also improved.2.Patients with grade 2 essential hypertension with insomnia and PSQI score>7 points.Adding ezopiclone to the traditional antihypertensive drugs can increase the antihypertensive effect of antihypertensive drugs.effect.3.Patients with grade 2 essential hypertension with insomnia and PSQI score>7 points can increase the antihypertensive effect of antihypertensive drugs by adding Shugan Jieyu capsule on the basis of traditional antihypertensive drugs.The role.4.The effect of ezopiclone and Shugan Jieyu capsule on the auxiliary blood pressure of patients with grade 2 essential hypertension with insomnia is similar. |
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