Clinical Study Of Tamsulosin Combined With Sodium Potassium Pitrate In The Treatment Of Lower Ureteral Calculi

Objective To explore the effect of combined tamsulosin capsules and sodium citrate sodium granules in the treatment of lower ureteral calculi,whether the effect of combination therapy is better than the use of a single drug alone,to evaluate the safety and efficacy of the combination drug.The majority of urologists provide a scientifically based drug regimen in the treatment of lower ureteral stones.Methods From December 2017 to December 2018,120 patients with good ureteral stones were diagnosed as ureteral calculi in the Department of Urology and Inpatient Department of the National University Hospital of Hubei University for Nationalities.The selected patients were randomly divided into three groups: A,B,and C according to the random number table method.Group A(tamsulosin group,40 patients): oral,0.2 mg/time,once a day;group B(Sodium hydrogen phosphate sodium granules group,40 patients): oral,early,middle 2.5g,5g at night,3 times a day;group C(combined group,40 patients): according to the medication regimen of group A and group B.The treatment period was 2 weeks,and the subjects were taken on time and in accordance with the dosage.The patients who participated in the trial were required to drink an average of 2000 ml-3000 ml per day and exercise appropriate activities and exercise.During the test,the diameter of the stone,the time taken to discharge the stone,the occurrence of adverse reactions after the drug,the onset of renal colic and the specific dose of the analgesic drug were recorded in detail during the test.All patients were treated with urinary color Doppler ultrasound or CT review to understand the specific situation of the row of stones.The efficacy and safety of three different medication regimens for the treatment of lower ureteral calculi were evaluated by comparing three groups of indicators.Result The stone-removing time of the three groups was A1(10.3±1.5)days,Group B(11.2±1.4)days,and Group C(8.0±1.7)days.The stone discharge rate of the three groups was 58.9%.47.5% in group B and 82.0% in group C;the doses of pethidine hydrochloride in group 3 were group A(105.4±16.8)mg,group B(122.9±25.7)mg,and group C(70.6±25.6)mg;There was a statistically significant difference in the time of stone discharge,the effect of stone removal and the dose of analgesic(P<0.05),but there was no significant difference in the age,sex,location and size of the stones,adverse drug reactions.(P > 0.05).Conclusion Clinically combined with tamsulosin and sodium hydrogen citrate to facilitate the excretion of the lower ureter stones,shortening the time of stone removal,and improving the efficiency of stone removal;tamsulosin combined with sodium hydrogen citrate can be used Significantly relieve acute renal colic caused by stone movement,reduce the incidence of acute renal colic,reduce the dosage of analgesic drugs,relieve pain for patients;clinically,it is safer to use,and it will not aggravate two drugs when combined Adverse drug reactions should be promoted clinically.