| Objective:By observing the clinical efficacy of Xiaoyan Zhitong ointment in the treatment of postherpetic neuralgia as well as observing experimental study on analgesic effect,exploring the action mechanism of Xiaoyan Zhitong ointment.Methods:1.Clinical research:according to the random method,105 cases with postherpetic neuralgia were divided into three groups,blank group,control group and treatment group with 35 cases.All PHN cases from department of dermatology of Yunnan provincial hospital of TCM,and signed informed consent.Three groups both received oral Traditional Chinese medicine,2 times everyday,150 ml every time.Blank group not received drugs for external use.Control group received Diclofenac Diethylamine Emulgel,2 times everyday.Treatment group received Xiaoyan Zhitong ointment,2times everyday.4 weeks as a period of treatment.Three groups were recorded and assessed before and after treatment by VAS ? AIS ? HAMD-17 score.According efficiency standard,then evaluated the total effectiveness.Blank group,control group and treatment group at the end of treatment after 4 weeks clinical follow-up.2.Experimental research:hot plate test and acetic acid writhing test were used to research the analgesic effect on mice.To study analgesic action of Xiaoyan Zhitong ointment.The above to organize information and use statistical approach to get the result.Results:1.This research selected 105 cases of postherpetic neuralgia,but 99 cases wereeventually completed,including,33 cases in the blank group(2 cases were dropped off),32 cases in the control group(3 cases were dropped off),34 cases in the treatment group(1 case was dropped off),a total of 6 cases.The total expulsion rate was 5.71%.2.Clinical efficacy:in the blank group,33 cases including 0 case was cured,4cases were obviously effective,21 cases were effective,8 case was invalid,the total effective rate was 75.8%.in the control group,32 cases including 0 case was cured,13 cases were obviously effective,17 cases were effective,2 case was invalid,the total effective rate was 93.7%.in the treatment group,34 cases including 0 case was cured,14 cases were obviously effective,19 cases were effective,1 case was invalid,the total effective rate was 97.1%.The treatment group,control group and blank group were compared,P<0.05,the differences were statistically significant,both were better than the blank group.The treatment group was compared with the control group,after statistical analysis,the P>0.05,the difference was not statistically significant.3.VAS score comparison:the comparison of VAS before treatment in three groups,the difference was not statistically significant(P>0.05).After treatment,the treatment group and control group showed varying degrees of decrease on score of VAS,compared with the blank group,the differences were statistically significant(P<0.05).After testing,the comparison among groups,there was no statistically significant difference between the treatment group and control group(P>0.05).4.AIS score comparison:the comparison of AIS before treatment in three groups,the difference was not statistically significant(P>0.05).After treatment,the treatment group and control group scores of AIS were declined,compared with the blank group,the differences were statistically significant(P<0.05).After testing,the comparison among groups,there was no statistically significant difference between the treatment group and control group(P>0.05).5.HAMD-17 score comparison:the comparison of HAMD-17 before treatment in three groups,the difference was not statistically significant(P>0.05).After treatment,the treatment group and control group showed varying degrees of decrease on score of HAMD-17,compared with the blank group,the differences werestatistically significant(P<0.05).the comparison among groups after testing,there was no statistically significant difference between the treatment group and control group(P>0.05).6.10 cases were followed up in the blank group,3 case was relapsed,the recurrence rate was 30%.12 cases were followed up in control group,1 case was relapsed,the recurrence rate was 8.33%.15 cases were followed up in the treatment group,0 case was relapsed,the recurrence rate was 0%.7.No adverse reactions occurred in the blank group.1 patient happened adverse reaction in the control group(32 cases),to a lesser degree.1 patient had adverse reaction in the treatment group(34 cases),to a lesser degree.The therapy of two cases were not discontinued.8.Xiaoyan Zhitong ointment can significantly increase the pain threshold of thermal stimulation in mice,compared with the blank group,P<0.05,the difference was statistically significant.It can significantly reduce the number of writhing induced by acetic acid in mice,compared with the blank group,P<0.05,the difference was statistically significant.Conclusion:1.Xiaoyan Zhitong ointment have a therapeutic action,can relieve pain,improve sleep,adjust mood and enhance the quality of life,The clinical curative effect of Xiaoyan Zhitong ointment is close to Diclofenac Diethylamine Emulgel.2.In the experimental study,Xiaoyan Zhitong ointment has obvious analgesic effect. |
PDF Full Text Request