Clinical Observation Of YixinTongmai Granule On Patients With Acute Coronary Syndrome Of Qi-Yin Deficiency And Phlegm-Blood Stasis Interaction After PCI

Objective:To observe the clinical effect of YixinTongmai Granule(YXTMG)on patients with acute coronary syndrome(ACS)of Qi-Yin deficiency and phlegm-blood stasis stagnation after PCI,and its effect on ventricular remodeling,so as to provide an objective and effective method for preventing ventricular remodeling after acute cardiovascular events.At the same time,it is proved that YixinTongmai Granule has good safety.Methods:Inclusion and exclusion criteria proposed in this study,Patients with acute coronary syndrome(ACS)with deficiency of qi and Yin and mutual obstruction of phlegm and blood stasis after PCI in changzhou hospital of traditional Chinese medicine from August 2017 to December 2018 were effectively included.A total of 60 subjects were included.According to the random number table method,all subjects were divided into control group and treatment group,with 30 cases/group.After PCI,the control group was given standardized western medicine treatment(including dual anti-platelet aggregation,anticoagulation,lipid-regulating and stable plaque,beta-blocker,AECI/ARB).The treatment group was given YiqiTongmai Granule on the basis of standardized western medicine treatment,one dose daily,morning and evening,for three months.Perfect preoperative routine examination and record the basic medical history of patients.The effect of YixinTongmai Granule on ventricular remodeling was observed and its clinical efficacy and safety were evaluated by comparing the blood lipid level,inflammation index,cardiac color Doppler ultrasound related index and TCM syndrome score between the two groups.Results:(1)Blood lipids:TC,TG and LDL-C levels in the two groups decreased significantly after three months of treatment compared with those before treatment(P<0.01);there was no significant difference in TC,TG and LDL-C levelsafter 7days of treatment between the two groups(P>0.05);After three months of treatment,the level of the treatment group was lower than that of the control group,and the difference was statistically significant(P>0.05).(P<0.01).(2)Inflammation indicators:hs-CRP and IL-6 levels in the two groups decreased significantly after three months of treatment compared with those before treatment(P<0.05);After 7 days of PCI treatment,the treatment group had lower IL-6 and hs-CRP values than the control group(P<0.01);the treatment group had lower IL-6 and hs-CRP values than the control group after three months of treatment(P<0.01).And the difference was statistically significant(P<0.05).(3)Cardiac color Doppler ultrasound indicators:After PCI treatment,the LVDd and LVEF of the two groups were significantly improved compared with those before treatment(P<0.01).The the LVDd and LVEF of the treatment group improved more significantly than those of the control group,and the difference was significant(P>0.05).There was statistical significance(P<0.05).(4)TCM syndrome integral:After PCI treatment,the syndrome integral of the two groups in March was significantly lower than that before treatment,after three months of treatment with PCI,the syndrome scores of different groups were significantly lower than those before treatment,and the difference was statistically significant(P<0.05).Compared with the control group,the difference between the two groups was statistically significant(P<0.01).Research conclusions:1.After this study,YixinTongmai Granule can significantly improve the clinical symptoms of patients with traditional Chinese medicine;2.YixinTongmai Granule can the triglyceride and total cholesterol levels of patients,low density lipoprotein,hs-CRP and IL-6 levels after surgery,and can inhibit ventricular remodeling;3.YixinTongmai Granule is safe.