| Objective:To investigate the onset age,seasonal aggravation,atopy history,clinical features,disease severity,life quality and laboratory examination in patients with atopic dermatitis(AD).Methods:Clinical data of 141 AD cases who were admitted to our dermatology department from October 2017 to December 2018 were collected.The onset age,seasonal aggravation,personal and family atopy history,clinical features,disease severity,life quality and laboratory examinationa including peripheral blood eosinophil(EOS)counts,serum total IgE and specific IgE antibodies,were analyzed.Results:141 AD cases were enrolled in this study.75(53.19%)cases were male and 66(46.81%)cases were female.The ratio of male to female was 1.14:1.The mean age was found to be 10.17±12.09 years(range from 1.5 years to 65 years).There were12 cases(8.51%)under 2 years old,99 cases(70.21%)from 2 to 12 years old,and 30cases(21.28%)over 12 years old.The mean onset age was 2.14±4.96 years.It was observed that 59.58%patients developed AD earlier than the age of 3 months.87.23%of the 141 AD cases underwent seasonal aggravation,and exacerbation in summer was most common,accounting for 38.30%.48 cases(34.04%)had at least one of the accompanied allergic diseases(asthma and allergic rhinitis),of which 18 patients(12.77%)were once diagnosed asthma and 30 cases(21.28%)were suffered from allergic rhinitis.Family history of atopy was noticed in 68.09%patients,of which family history of asthma,allergic rhinitis,allergic conjunctivitis and eczema/AD was23.40%,46.81%,12.77%and 27.66%,respectively.Some clinical signs were found in over 70%AD cases as follows:xerosis(97.87%),history of flexion dermatitis(93.64%),eczema/AD before 12 years old(93.62%),visible flexural dermatitis(87.23%),eczema/AD before 2 years old(87.23%),chronic recurrent dermatitis(82.98%),white dermographism(76.60%),itching upon sweating(76.60%),disease influenced by environmental factors(76.60%)and facial pallor/facial erythema(74.47%).Facial pallor/facial erythema had higher frequencies in the infants and the incidence of facial pallor/facial erythema was declined with the age.However,the frequencies of white dermographism,anterior neck folds and palmar hyperlinearity increased with age.The mean SCORAD of 141 cases was 50.74±17.59.The fraction of patient with,respectively,mild,moderate and severe AD according to SCORAD was 10.64%,53.19%and 36.17%.Moderate and severe AD were more common in all age groups.The mean SCORAD of patients complicated with asthma/allergic rhinitis was64.69±24.23,which was higher than those without asthma/allergic rhinitis(52.94±17.91)(P<0.05).The mean CDLQI of children group under 12 years old was 8.19±3.30.The mean DLQI of adolescence/adult AD patients over 12 years old was 14.90±5.51.AD patients had a statistically significant positive correlation between DLQI/CDLQI and SCORAD(r=0.67 and 0.71,respectively).The mean peripheral blood EOS level was0.41±0.36×10~9/L and 39 cases(27.66%)had an elvated values.Mean serum total IgE level was 754.28±1316.82 IU/ml and 72 cases(51.06%)had elevated serum total IgE level.The peripheral blood EOS count and serum total IgE level of AD patients increased with the aggravation of the disease(P<0.05).Serum specific IgE antibodies were positive in 91.49%of 141 cases.House dust mite,artemisia argyi and willow/aspen/elm were the top 3 inhalant allergens.Egg white,cow's milk and peanut were the top 3 food allergens.House dust mite was the most common inhalant allergen in all age groups.The most common food allergen was cow's milk in preschool children group,egg white in school-age children group and marine/freshwater fish in adolescence/adult group,respectively.Conclusion:1.Majority of AD patients are infants and children.The onset age of AD patients is early and 59.58%patients develop AD before the age of 3 months.AD patients undergoing exacerbation in summer is most common and allergic rhinitis is the most common in personal and family history of atopic diseases.2.Facial pallor/facial erythema has higher frequencies in the infants and the incidence of facial pallor/facial erythema is declined with the age.However,the frequencies of white dermographism,anterior neck folds and palmar hyperlinearity increase with age.3.Moderate and severe AD are found more common in all age groups.The disease severity of AD patients with asthma/allergic rhinitis is more serious than those without asthma/allergic rhinitis.There is a significant positive correlation between CDLQI/DLQI and SCORAD.4.The peripheral blood EOS count and serum total IgE level of AD patients increased with the aggravation of the disease.House dust mite is the most common inhalant allergen in all age groups.The most common food allergen is cow's milk in preschool children group,egg white in school-age children group and marine/freshwater fish in adolescence/adult group,respectively. |
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