Prevalence Of Candida Albicans And Its Relationship With Early Childhood Caries Among Children Of Three Ethnic Groups(Han, Uygur, Mongolian) In Bortala Mongol Autonomous Prefecture Of Xinjiang Uygur Autonomous Region

Objective:Study on the distribution of Candida albicans(Ca)in Bortala Region of Xinjiang province,which are closely connected to caries of young children among 3~5years old children of Mongolian,Uygur and Han,and analyze the differences in polymorphisms of Ca between the three ethnic groups,can provide scientific basis for the early prediction and prevention of caries locally.Methods:1089 healthy children aged 3 to5 years old(Mongolian 136,Uygur 403 and Han 550,568 males,521 females)were randomly selected by stratified and cluster sampling method.The early childhood caries group were 786 and the caries free group were 303.Dental plaque samples were separately collected from the carious tooth tissues and from supragingival tooth sites.They were isolated and cultured by different medium,and identified by Gram stain,germ tube test,PCR method,internal transcribed spacer region sequencing methods,and typed by PCR-25SrDNA genotype.Pearson?2 test and Trend chi square correlation were used to analyze the difference between different genotypes of Ca different nationalities and sexes and the relationship between DMFT classification and detection of Candida albicans.Results:The detection results of the samples were as follows:the detection rate of Ca the ECC group was[14.4%(113/786)],and that in the CF group was[7.6%(23/303)].The difference between the two groups was statistically significant(?2=9.214,P=0.002);the detection rates of Ca Mongolian,Uygur and Han are respectively[11.8%(16/136)],[17.9%(72/403)],[8.7%(48/550)].The difference between the three ethnic groups was statistically significant(?2=17.848,P<0.001).Among male children,the detection rates of Ca Mongolian,Uygur and Han were respectively[10.0%(8/80)],[21.7%(44/203)],[8.4%(24/285)].The difference in detection rate among males of three ethnic groups was statistically significant(?2=18.887,P<0.001).Among female children,the detection rates of Ca Mongolian,Uygur and Han ethnic groups were respectively[14.3%(8/56)],[14.0%(28/200)],[9.1%(24/265)].There was no significant difference in the detection rate of female ethnic(?2=3.206,P=0.201).In the ECC group,the detection rate of Uyghur and Han nationality Ca significantly correlated with the number of missing teeth(Uygur:Trend chi square?~2=11.11,P=0.001;Han:Trend chi square?~2=8.15,P=0.004).Totally 136 Ca samples were divided into 3 types by PCR-25SrD N A m ethodwas type A[55.1%(75/136)].Conclusions:Uygur young children in Bortala area of Xinjiang province are susceptible to Candida albicans;Uygur male children carrying Ca are more susceptible to dental caries;Ca may be a risk for early childhood caries.There is no specific cariogenic genotype in Ca,and ethnic factors are not associated with the genotype of Ca.