| Objective: To explore the curative effect of jiaotai gujing decoction on premature ejaculation of heart and kidney.Methods: Seventy patients were randomly divided into two groups: the treatment group(n = 35)and the control group(n = 35).In the treatment group,35 patients regularly took jiaotai gujing decoction formula granules without decoction,twice a day,once a bag,and washed with warm water for 200 ml.The 35 patients in the control group were treated with imusak tablets,0.5g qd,and taken orally after meals.The patients in the treatment group and the control group returned to the hospital for a visit after one course of medication,and the number of medication,dosage,adverse reactions,clinical overall impression change after medication(CGIC)and related observation indexes were recorded.After 2 courses of medication,the patient will return to the hospital for visit,and relevant data will be recorded.Finally,according to the statistical data,the changes of relevant observation indexes before and after 1 course of treatment and 2 courses of treatment were compared to explore the effectiveness and adverse reactions of the drugs.Results:1,Comparison of IEIT between the two groups: after 4 weeks and 8 weeks of treatment,inter-group and intra-group comparison of IEIT was conducted.The treatment group was 1.130.39(min)before treatment,2.20 0.87(min)after 4 weeks of treatment,and 3.94 1.30(min)after 8weeks of treatment.In the control group,IEIT was 1.18 0.43(min)before treatment,2.12 1.03(min)after 4 weeks of treatment,and 3.17 1.25(min)after 8 weeks of treatment.At 4 weeks of treatment and 8 weeks of treatment,there were significant differences in IEIT between the treatment group and the control group before and after self-treatment(P<0.001),and no significant differences in IEIT between the treatment group and the control group at 4 weeks of treatment(P=0.72>0.05). At 8 weeks of treatment,there were significant differences in IEIT between the two groups after treatment(P<0.001).At 4 weeks of treatment,the effective rate was 45.7% in the treatment group and 31.4% in the control group compared with that before treatment,and there was no significant difference between the two groups(P=0.21>0.05).At 8 weeks of treatment,the effective rate was88.0% in the treatment group and 71.4% in the control group compared with that before treatment.The difference between the two groups was statistically significant(P=0.04<0.05).2,Comparison of TCM syndrome scores: the scores of TCM syndromes in the two groups were compared between the two groups at 4 weeks and 8 weeks after treatment.The scores of TCM syndromes in the treatment group were 19.80 2.63 before treatment,14.40 3.44 after treatment,and 8.11 3.33 after treatment at 8 weeks.The control group was 19.77 3.03 before treatment,14.82 3.11 after 4 weeks of treatment,and 10.97 3.07 after 8 weeks of treatment.4weeks treatment the treatment group and control group in its TCM syndrome integral contrast before and after the treatment and treatment of 8 weeks when compared to all have significant difference(P<0.001),treatment of 4 weeks between treatment group and the control way of TCM syndrome integral,there was no significant difference(P=0.58>0.05),at 8 weeks treatment,the treatment group compared with contrast between the way of TCM syndrome integral,there are significant differences(P<0.001).At 4 weeks of treatment,the effective rate was 45.7% in the treatment group and 31.4% in the control group compared with that before treatment.There was no significant difference between the two groups(P=0.21>0.05).At 8 weeks of treatment,the effective rate was 88.0% in the treatment group and 71.4% in the control group.There were significant differences between the two groups(P=0.04<0.05).3,Comparison of overall clinical impression: CGIC between and within the two groups was compared after 4 weeks and 8 weeks of treatment.CGIC before treatment was 0 in both groups,and 0.97 1.01 in the treatment group after 4 weeks of treatment,and 2.17 0.58 after 8 weeks of treatment.The control group was 0.88 0.99 after 4 weeks of treatment,and 1.71 0.98 after 8 weeks of treatment.At 4 weeks of treatment and 8 weeks of treatment,there were significant differences in CGIC between the treatment group and the control group before and after self-treatment(P<0.001);at 4 weeks of treatment,there were significant differences in CGIC between the treatment group and the control group(P=0.04>0.05);at 8 weeks of treatment,there were significant differences in CGIC between the treatment group and the control group(P<0.001).At4 weeks of treatment,the improvement rate was 57.1% in the treatment group and 57.1% in the control group(P=0.69>0.05).At 8 weeks of treatment,the improvement rate was 91.4% in the treatment group and 85.7% in the control group.There was a significant difference in the improvement rate between the two groups,and the difference was statistically significant(P=0.03<0.05).Conclusion: After clinical observation,the self-designed jiaotaigujing decoction has a good effect on premature ejaculation of heart and kidney,and its effect is better than imusac tablet.In addition,there was no adverse reaction,expanding the TCM prescription for the treatment of premature ejaculation in clinical practice,which can provide reference for clinicians. |
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