Study On The Correlation Of TCM Syndromes,Constitution And Risk Factors Of PCOS In Kunming

Objective: To explore the TCM syndromes,constitution distribution and risk factors related to PCOS in Kunming area,and to find out the correlation between life factors and TCM syndromes.It is hoped that this study will provide a basis for the future research on the diagnosis and treatment of PCOS diseases in Kunming.Methods: Through collecting and sorting out the disease information of 150 PCOS patients in Kunming area,using medical statistical method to calculate the data,using descriptive statistics,Pearson X2 test,one-way ANOVA,Logistic binary regression and other statistical methods to carry out medical statistics,the distribution law of TCM syndromes and the characteristics of constitution types of PCOS patients in Kunming area were analyzed,and TCM syndromes were explored.The correlation between type I and constitution and life factors of TCM.Result:1.Through investigating 150 PCOS patients in Kunming area,the most common TCM syndromes are kidney-yang deficiency(26.67%),the other syndromes are spleen deficiency,phlegm-dampness(23.33%),liver meridian dampness-heat(20%),liver depression and blood stasis(16%)and kidney-yin deficiency(14%).2.The average age of the 150 patients was 24.01 and 4.03 years old.There were no significant differences among the age groups(P=0.877>0.05),including 15-18 years old(16 cases,10.67%),19-23 years old(50 cases,33.33%),24-28 years old(55cases,36.67%),29-33 years old(18 cases,12%)and 34-39 years old(11 cases,7.33%).3.The average age of menarche in 150 patients was(13.56±1.45 years old).The average age of menarche in each type was arranged as follows: kidney-yang deficiency type(14.08±1.64 years old)>liver-meridian dampness-heat type(13.83±1.29 years old)>kidney-yin deficiency type(13.33±1.20 years old)>liver-stagnation and blood stasis type(13.21±1.50 years old)>spleen-deficiency and phlegm-dampness type(13.11±1.28 years old).The average age of menarche in patients with kidney-yang deficiency type was older than that of spleen-deficiency and The difference was significant(P=0.038<0.05).There was no significant difference in the age of menarche between the other groups(P> 0.05).4.Among the 150 patients,52 were infertile,of which 65.38% were primary infertility and 34.62% were secondary infertility.5.150 patients' occupations were mainly concentrated in two social groups: office workers(45.33%)and students(34.67%).Service industry was relatively small(20%).There was no significant difference in occupational distribution among different types of syndrome(P=0.783>0.05).Most of the PCOS patients surveyed had higher education level(41 College students,study).With the increase of education level,the prevalence of PCOS increased.6.Kidney-yang deficiency type: exercise degree was negatively correlated with kidney-yang deficiency(P=0.034<0.05);serum LH(luteinizing hormone)was relatively high(P=0.0036<0.01),PRL(serum prolactin)was relatively low(P=0.003< 0.01).7.Kidney Yin Deficiency Type: Blood TESTO(testosterone)is relatively high(P= 0.013 < 0.05),which is negatively correlated with BMI(P = 0.001 < 0.01),normal or lean.8.Spleen-deficiency phlegm-dampness type: dietary preference was positively correlated with spleen-deficiency phlegm-dampness type(P=0.024<0.05);positively correlated with BMI(P=0.002<0.01),overweight or obesity;positively correlated with WHR(P=0.005< 0.01),showing central obesity.9.Liver depression and blood stasis type: Mental factors were positively correlated with liver depression and blood stasis type(P=0.008<0.01);blood PRL was relatively high(P=0.009<0.01),and negatively correlated with WHR(P=0.045<0.05),rarely showing central obesity.10.Damp-heat type of liver meridian: PRL in blood was relatively high(P=0.022<0.05).Acne and hairy were the main clinical manifestations(P=0.009<0.01,P=0.018<0.05).11.96% of the PCOS patients in Kunming area were found to have a biased constitution.The frequency of constitution types was as follows: Yang deficiency(26%)> phlegm-dampness(18.67%)= damp-heat(18.67%)> Yin deficiency(10%)>blood stasis(8.67%)> qi depression(7.33%)> Qi deficiency(6.67%)> calm temperament(4%).No special temperament was found in the investigated patients.12.The correlation between constitution and syndrome types: Yang deficiency and kidney-yang deficiency(P=0.00<0.01)and spleen deficiency and phlegm-dampness(P=0.033<0.05);Yin deficiency and kidney-yin deficiency(P=0.006<0.01);dampness-heat and liver meridian dampness-heat(P=0.005<0.01);blood stasis and kidney-yang deficiency(P=0.03<0.05).Conclusion:1.The most common TCM syndromes of PCOS in Kunming are kidney-yang deficiency,spleen deficiency,phlegm-dampness and liver meridian dampness-heat.2.Exercise can be regarded as the protective factor of kidney-yang deficiency,diet preference as the risk factor of spleen deficiency and phlegm-dampness,and mental factor as the risk factor of liver stagnation and blood stasis.3.Yang deficiency is the susceptible constitution of kidney-yang deficiency syndrome and spleen deficiency phlegm-dampness syndrome;Yin deficiency is the susceptible constitution of kidney-yin deficiency syndrome;dampness-heat is the susceptible constitution of liver meridian dampness-heat syndrome;blood stasis is the susceptible constitution of kidney-yang deficiency syndrome.4.The age of menarche is the latest in patients with kidney-yang deficiency and the earliest in patients with spleen deficiency and phlegm-dampness.