Therapeutic Effect Of Anwei Decoction Combined With Quadruple Therapy On Helicobacter Pylori Gastritis

Objective: On the basis of quadruple therapy,“Anwei Decoction”was combined to treat patients with Helicobacter pylori-associated gastritis and cold-heat syndrome.Observing the eradication and recurrence of Helicobacter pylori by “Anwei Decoction”and the intestinal flora after treatment,during treatment and after treatment.The effect of “Anwei Decoction”can improve the clinical efficacy by affecting the eradication and recurrence of Helicobacter pylori and improving the imbalance of intestinal flora,and provide a theoretical basis for the treatment of Helicobacter pylori-associated gastritis with integrated Chinese and Western medicine.Methods: From August 2017 to September 2018,a total of 80 outpatients and inpatients in the spleen and stomach department of our hospital were admitted.According to the random number table method,the observation treatment group(group A)and the control treatment group(group B)were divided into two groups,40 cases in each group.Group A was treated with quadruple therapy + Anwei Decoction for 14 days.Group B was treated with quadruple therapy for 14 days.To evaluate the comprehensive efficacy of the patients,to observe the clinical symptoms of the two groups before and after treatment,to calculate the symptom scores before and after treatment,to detect the eradication rate 4 weeks after the treatment of the foot treatment,and to detect the Hp in the Hp-negative patients at 12 weeks to understand the recurrence.The gut smear test method was used to analyze the degree of intestinal flora imbalance on the 7th and 14 th day of treatment,and the adverse reactions during the treatment were recorded.Results:(1)Overall clinical efficacy: After 14 days of treatment,the total effective rate of group A was 92.21%,and the total effective rate of group B was 82.50%.The total effective rate in group A was significantly higher than that in group B.The difference was statistically significant(P<0.05).The curative effect is better than the B group.(2)Symptom improvement: a.Symptoms In the total score group,the total scores of symptoms after treatment in group A and group B decreased significantly,and the difference was statistically significant(P<0.05).b.The total scores of the symptoms were compared with the total scores of the symptoms after treatment in group B.The total scores of symptoms in group A were significantly decreased after treatment,and the difference was statistically significant(P<0.05).c.In the single symptom score group,the group A was not significantly improved except for the change of the drug,and the other symptom scores were improved before the treatment(stomach sputum,stomach cramps,swallowing,stool smashing,dry mouth and bitter mouth,mouth is not thirsty,P <0.05);group B,poor appetite,mouth and not thirsty,two symptoms compared with before treatment,P>0.05,single symptom score of stool erosion,dry mouth and mouth pain Before treatment,and the symptoms of stomach cramps,stomach cramps,and swollen stomach were significantly improved compared with those before treatment(P<0.05).d.Comparison of single symptom score group,the improvement of group A symptom group A was better than group B(stomach cramps,ingestion,stomach cramps,stool erosion P<0.05),and the remaining symptoms There were no significant differences in group changes.(3)Hp eradication rate and recurrence rate: After 4 weeks of treatment,the eradication rate of group A was 97.37%;the eradication rate of group B was 80.00%.There was a statistically significant difference in Hp eradication rate between the two groups(P<0.05).After 12 weeks of treatment.The recurrence rate was 0 in group A and 15.63% in group B.The difference of Hp recurrence rate between the two groups was statistically significant(P<0.05),indicating that the recurrence rate of Hp in group B was higher than that in group A.(4)Analysis of intestinal flora imbalance after treatment and treatment: On the 7th day of treatment,1 patient in group A had grade I intestinal flora imbalance,1 patient had grade II intestinal flora imbalance,18 patients in group B had grade I intestinal flora imbalance,and 1 patient developed II degree intestinal flora imbalance,statistically significant difference between the two(P <0.05);on the 14 th day of treatment,1 patient in group A had II degree intestinal flora imbalance,and 9 patients in group B showed I Intestinal flora was dysregulated,and one patient developed II degree intestinal flora imbalance,the difference was statistically significant(P<0.05).(5)Drug safety analysis: There were no adverse drug reactions in group A,and 3 patients in group B developed mild diarrhea,suggesting that Anwei Decoction combined with quadruple therapy for the treatment of cold and hot syndrome Helicobacter pylori gastritis is safe and reliable.Conclusion: “Anwei Decoction”combined with quadruple therapy can effectively improve the clinical symptoms of patients with Helicobacter pylori-associated gastritis and fever syndrome,improve the eradication rate of Helicobacter pylori,and reduce the recurrence rate;The intestinal flora with PPI and antibiotic treatment has Regulating effect.The treatment is safe and worthy of clinical application.