| Research purposes:Based on the medical theory of the motherland,this study was conducted to observe the changes of serum y-aminobutyric acid(GABA),glutamic acid(Glu)and various sleep scales before and after treatment with Zhengzao Capsule in elderly patients with yin deficiency and fire-type insomnia.To evaluate the clinical efficacy of treating insomnia,and to explore the mechanism of action of Zhenzao Capsule in treating insomnia in the elderly.Research method:In this study,60 patients with primary insomnia 60-90 years old who met the inclusion criteria and exclusion criteria were randomly divided into a treatment group and a control group,with 30 patients in each group.The treatment group took Zhenzao capsules and the control group took Shumian capsules.Taking 28 days as an observation period,the patient was followed up for 14 days,and the clinical efficacy was compared after 28 days of continuous medication:including the changes of the values before and after GABA/GLU treatment,and the structural changes of various sleep scales,thus clinical use of Zhenzao Capsules.Explore the mechanism of action of insomnia.Research result:1.TCM syndrome efficacy:1 group of internal phase comparison:After the drug intervention,the scores of TCM syndromes in the two groups showed P<0.01 compared with the drug before use,which was statistically significant;After treatment,the treatment group showed a P<0.05 improvement in patients with insomnia,dizziness and tinnitus compared with the control group,which was statistically significant;both of them improved other clinical symptoms(P>0.05),and there was no statistical significance.3 From the overall efficiency point of view:the total effective rate of Zhenzao capsule group was 86.67%,and that of Shumian capsule group was 80%,compared with P<0.05,which was statistically significant.2.Pittsburgh Sleep Quality Index Number Table(PSQI):1 group internal phase comparison:The scores of each item in the PSQI scale after the two groups of medications were statistically significant(P<0.05);The two groups were statistically significant(P<0.05)after shortening the time of falling asleep,improving sleep disturbance,and alleviating daytime dysfunction;especially in extending the patient's sleep duration and improving sleep efficiency(P<0.01).There was significant statistical significance;there was no statistically significant difference between the two groups in improving sleep quality and reducing the number of hypnotic drugs used(P>0.05).3 In terms of overall mean difference,the efficacy of the two groups was significant after treatment.Statistical significance(P<0.01).3.Hamilton Anxiety Scale(HAMA):The internal mean time of the two groups was lower than the previous ones,P<0.05,indicating that both groups of drugs can improve the anxiety symptoms of the patients;Interphase:There was no significant difference between the treatment group and the control group(P=0.328>0.05),indicating that there was no significant difference in the improvement of anxiety symptoms between the two groups.4.From the clinical indicators:the internal phase of the 1 group:the total difference in serum GABA content between the two groups increased after administration,the total difference in GLU content was lower than before treatment,P<0.01;The comparison between the two groups:the total difference after the two groups of medications were treated by SPSS software and obtained P<0.01,which was statistically significant.Analysis conclusion:1.Zhenzao Capsule can improve the TCM syndromes and clinical symptoms of elderly patients with insomnia,and improve the sleep quality and life function of patients with insomnia,and the clinical effect is remarkable:2.Zhenzao Capsule may improve the symptoms of insomnia and anxiety in the elderly through the regulation mechanism of GABA/GLU homeostasis. |
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