Evaluation Of Zhenzao Capsule In The Treatment Of Senile Simple Chronic Insomnia Based On Rs-fMRI

Objective:In this study,guided by the theory of traditional Chinese medicine,we observed the changes of PSQI,TCM symptom score and ReHo value of Rs-fMRI in the treatment of senile insomnia patients with Yin deficiency and Fire exuberance by using the method of random and positive control.We evaluated the clinical efficacy of Zhenzao Capsule in the treatment of senile insomnia patients with Yin deficiency and Fire exuberance,and explored the possible mechanism of Zhenzao Capsule in improving the sleep status of insomnia patientsMethods:Thirty insomniacs over 60 years old who met the diagnostic criteria of elderly patients with simple chronic insomnia and the syndrome differentiation criteria of Yin deficiency and Fire exuberance were divided into two groups,the treatment group and the control group,with 15 cases in each group according to the principle of randomization and the way of parallel control.The patients in the treatment group were treated with Zhenzao capsule(in-hospital preparation of Jiangsu Traditional Chinese Medicine Hospital).The patients in the control group were treated with Tianwang Buxin Pill.The total treatment time was 8 weeks as a course of treatment,i.e.one observation period,and the observation time was 8 weeks.After one course of treatment,PSQI and TCM syndrome curative effect score of clinical patients were evaluated.To explore the therapeutic mechanism of Zhenzao Capsule in the treatment of senile insomnia patients with Yin deficiency and fire exuberance,the ReHo scores of each brain area of Rs-fMRI before and after treatment were monitored and analyzed.Results:1.The reduction rate of TCM syndrome score in the treatment group was higher than that in the control group,with statistical significance(P<0.05),suggesting that the improvement of TCM syndrome score in the treatment group was better than that in the control group2.The reduction rate of PSQI in the treatment group was higher than that in the control group before and after treatment(P<0.05),suggesting that the improvement of PSQI in the treatment group was better than that in the control group.3.Compared with the SAS scores before and after treatment,the SAS scores in the treatment group were higher and much lower than those in the control group,with significant statistical significance(P<0.01),but the SDS scores were not significantly reduced,and there was no significant statistical significance.It is suggested that Zhenzao capsule can improve the anxiety symptoms of elderly patients with chronic insomnia better,but not depression symptoms4.Compared with the whole brain ReHo values,the ReHo values of left inferior temporal gyrus,left superior temporal gyrus,left parietal angular gyrus and right fusiform temporal gyrus in the treatment group increased,while the ReHo values of left inferior temporal gyrus,left marginal hippocampal gyrus and right inferior temporal gyrus decreased,with significant difference between the two groups(P<0.05)Conclusions:1.Zhenzao capsule can improve the clinical symptoms of elderly insomnia patients with Yin deficiency and Fire exuberance.It has significant clinical effect and improves the quality of life of elderly patients with simple chronic insomnia2.Zhenzao capsule reduced PSQI value of patients with simple chronic insomnia,and significantly improved the sleep quality of patients3.Zhenzao capsule can reduce the SAS score of chronic insomnia patients and improve the anxiety symptoms of patients4.The mechanism of Zhenzao Capsule in the treatment of elderly patients with simple chronic insomnia may be related to the regulation of abnormal functional activities in temporal lobe and hippocampus.