Clinical Analysis Of The Effects Of Huayu Jiedu Xuebijing On Different Syndromes Of Sepsis

Objective:Study the curative effect of conventional western medicine combined with Xuebijing injection on different syndromes of sepsis.Methods:Select 60 patients with ICU sepsis admitted to Suzhou Chinese Medicine Hospital affiliated to Nanjing University of Traditional Chinese Medicine from December 2016 to December 201 8,they are the venom heat group,the blood stasis group,and the phlegm group,and set up a control group with 20 patients on the basis of random method.Take 7D as a course of treatment,the control group used physiological saline 150ml on the basis of supportive treatment,the treatment group used Xuebijing injection 50ml(mix in 100ml normal saline)on the basis of supportive treatment.Observing the changes of patients'APACHE II score,common inflammatory index(WBC,N,CRP,PCT),arterial blood lactate and special inflammation index(IL-6,IL-8,TNF-a,YKL-40,YKL-40,SE-selectin,SP-selectin,SL-selectin)before treatment and after 7 days.Comparison of treatment efficiency after 7 days and 28D mortality in four groups.By comparing the changes in the observation indicators of each group of patients,compared the differences in efficacy between different syndrome types.Results:1.The difference between the four groups' APACHE ? score,WBC,N,CRP,PCT,Lac,IL-6,IL-8,TNF-a,YKL-40,YKL-40,SE-seIectin,SP-selectin,SL-selectin before and after treatment was statistically significant(P<0.05).2.Compared with the control group,the APACHE II score and treatment efficiency,WBC,CRP,IL-6,IL-8,TNF-a,YKL-40,SE-selectin in the treatment group were significantly higher than those in the venom heat group,the blood stasis group and the phlegm group(P<0.05),however,there was no significant difference between N and PCT(P>0.05).3.Compared with the control group,there was no significant difference in Lac between the venom heat group and the phlegm group(P>0.05),but the blood stasis group was statistically significant(P<0.05).4.Compared with the control group,there were significant differences in SP-selectin and SL-selectin between the venom heat group and the blood stasis group(P<0.05),but there was no significant difference in the phlegm group(P>0.05).5.Compared with the phlegm group,the difference of SE-selectin between the venom heat group was statistically significant(P<0.05),and the difference of SL-selectin between the venom heat group and the blood stasis group was statistically significant(P<0.05).6.There was no significant difference in mortality between the four groups after 28 days of treatment(P>0.05).7.There was no significant difference in APACHE II score,treatment efficiency,WBC,N,CRP,PCT,Lac,IL-6,IL-8,TNF-a,YKL-40,and SP-selectin between the three treatment groups(P>0.05).Conclusion:1.Both conventional Western treatment and combination of Xuebijing can reduce the APACHE ? score and some serum indicators in patients with sepsis,reduce the degree of infection.2.Combined use of Xuebijing inj ection is superior to traditional Western medicine,the combination of Xuebijing injection can effectively reduce the APACHE II score and some serum indexes of patients with sepsis,reduce the inflammatory response and improve the efficiency of clinical treatment.3.Xuebijing injection may be more effective for toxic heat syndrome and blood stasis syndrome,but need further clinical proof.