Comparison Of Methods For Constructing The End Point Of Clinical Curative Effect Evaluation Of Myocardial Infarction

Objectives1.To investigate the incidence of hospitalization and follow-up end-point events with myocardial infarction patientsin in eight Chinese medicine hospital.Entropy method and frequency statistics were used to construct the end point index of clinical efficacy evaluation of TCM for myocardial infarction.2.Compared with the former principal component analysis method to construct the index,the method of selecting the end point index of clinical curative effect evaluation of Chinese medicine for myocardial infarction was validated and perfected,expecting to provide a new methodological demonstration for the evaluation of the end point index.MethodsA retrospective cohort study was designed.Myocardial infarction patients from eight three level chinese medicine hospital,including Shandong Provincial Hospital of Traditional Chinese Medicine,were selected to collect the basic information,the application of traditional chinese medicine injections,the occurrence of end points during hospitalization and the oral chinese medicine(proprietary chinese medicine,chinese medicine decoction),the occurrence of end-point events during the follow-up.The entropy weight method was used to calculate the weight of the index during hospitalization and the follow-up,taking into account the frequency weight of each index,useing multiplicative synthesis normalization method to calculate the comprehensive weight,proveing the clinical significance,in the end,establishing the end point index for evaluating the curative effect of TCM on myocardial infarction.The results were compared with the results obtained from the previous principal component analysis,referenceing the literature,randomized controlled trials,epidemiological investigation on the myocardial infarction of the end index selectionas,which to verify the scientific endpoint selection method,with a view to provide a new methodological demonstration for the end point evaluation.Results1.Cardiac death,acute heart failure,severe arrhythmia as the primary endpoint during hospitalization,post-infarction angina,revascularization as the secondary endpoint;cardiac death,reinfarction,heart failure as the primary endpoint during follow-up,re-admission,post-infarction angina was the secondary endpoint.2.Compared with the results of the former principal component analysis,the results showed that the main endpoints of hospitalization and follow-up were exactly the same,only the secondary endpoints were different,and the results maintained a higher unity with the previous study.Referenceing literature research,randomized controlled trials,epidemiological investigation of selected end-point indicators,the results obtained by the two methods and this three selected indicators have strong consistency.Fully demonstrate the reliability and validity of the principal component analysis and entropy method for the optimal index of the end point of myocardial infarction.ConclusionPrincipal component analysis and entropy method are both suitable for the selection of the end point of clinical curative effect evaluation of traditional Chinese medicine for myocardial infarction.This time entropy method combined with the use of mathematical statistics model provides a new methodological demonstration for the evaluation of the end-point index.