Analysis On Constitutional Characteristics Of Traditional Chinese Medicine With Different Phenotypes Of Aging And Its Relationship With Bone Metabolism

Objective To investigate the prevalence of senile dementia,summarize the distribution of TCM constitution of different phenotypes,analyze the possible risk factors of frailty and the relationship between frailty phenotype and bone metabolism,and analyze the relationship between TCM constitution and frailty.Methods In the questionnaire survey,150 patients were investigated and analyzed.According to the FRAIL scale scores,the patients were divided into non-fatigue group,pre-fatility group and debilitating group,and the constitution type,body mass index(BMI)of each group were recorded.Osteocalcin(BGP)and serum 25-hydroxyvitamin D(25-(OH)D)data were analyzed.General data were recorded using statistical descriptions and analyzed using Fisher's exact test and analysis of variance.,An orderly and multi-classified logistic regression analysis was used to analyze the correlation between the weak phenotype and 25-(OH)D,BGP,debilitating phenotypes and different TCM constitutions.Result1.The senile patients were weaker and their pre-senile rates were 48.0% and 37.3%,respectively.There were significant differences in age,BMI,osteocalcin and serum 25-(OH)D(p <0.05)between different frailty phenotype groups,Difference(p> 0.05).2.Common physique in elderly patients include qi deficiency(10.7%),blood stasis(10%),mild(9.3%),qi deficiency and blood stasis(9.3%,47.4%).3.The distribution of physical constitution in different age groups is inconsistent.The common physique of 65-75-year-olds is mainly qi deficiency and phlegm and dampness(15.6%).The common constitutions of 76-85-year-olds are qi deficiency(10.3%)and yin deficiency(10.3%).Qi deficiency and blood stasis(10.3%),blood stasis(10.3%),common constitution of elderly over 85 years old were qi deficiency(14%)and blood stasis(14%).4.The physical distribution of different debilitating phenotypes was different.The common constitutions of non-debilitated patients were mainly mild(45.5%);the common constitutions of debilitating preterm groups were qi deficiency(10.7%)and qi deficiency(10.7%);the common constitution of debilitated patients Qi deficiency(12.5%).5.Regression analysis: According to the multivariate logistic regression analysis,age,sex,BMI,serum 25-(OH)D and osteocalcin were used as dependent variables.The standard was 0.05.After adjusting for age and sex,the decline was still related to BMI,serum 25-(OH)D and osteocalcin(OR: 1.263,1.371,1.236;p: 0.001,0.000,0.000).Taking the weak phenotype as the dependent variable and the common TCM constitution of the elderly as the independent variable,the multivariate logistic regression analysis was conducted with the multivariate Logistic regression analysis,the significance was 0.05,the BMI,serum 25-(OH)D weakness and qi deficiency,blood stasis,qi and blood stasis,qi deficiency phlegm were significantly related(OR:0.059,0.062,0.015,0.039;p: 0.013,0.015,0.002,0.009);corrected BMI,serum 25-(OH)D,osteocalcin,the weakness is still associated with blood stasis,qi deficiency and blood stasis are closely related(OR: 0.066,0.009,p: 0.048,0.006).Conclusion 1.Senile patients with a higher risk of debilitation.2.There was no correlation between age and gender,and there was a correlation between BMI,serum 25-(OH)D and osteocalcin.BMI and serum 25-(OH)D,osteocalcin can predict the risk of debilitation.3.Compared with the normal quality,the elderly common several biased physique and weakness exist,including blood stasis and qi deficiency and blood stasis and weakness are closely related to these two constitutions should pay attention to early intervention,delaying the decline.