The Study Of Brain FMRI In The Resting State And Task State Of First-episode Patients With Mild And Moderate Depression Before And After Treatment

Part Ⅰ The study of brain resting-state fMRI based on local consistency of first-episode patients with mild and moderate depression before and after treatmentObjective To explore the functional state of the abnormal brain regions in first-episode patients with mild and moderate depression using resting-state functional MRI(rfMRI)technology,which would provides a new idea for the exploration of the pathogenesis of depression and the evaluation of the effect of clinical treatment.Methods 14 first-episode patients with mild and moderate depression[live up to DSM-Ⅳ diagnostic criteria for depression,Hamilton Depression Scale(HAMD-17)score 17-24 points]and 14 matched healthy volunteers were examed by rfMRI.The KCC of voxel is calculated based on the regional homogeneity(ReHo)method,and the ReHo value of each voxel of the whole brain is obtained.The 8 patients underwent rfMRI scan after 6 weeks of drug treatment.The statistical analysis is completed by SPM8 software package.Results ReHo was significantly higher than the control group in the brain area of bilateral part of the brain the amount of depression group,bilateral fusiform gyrus,bilateral cingulate gyrus,right cerebellum foot,right thalamus,right middle temporal gyrus,left medial dorsal nucleus of thalamus etc(P<0.05,K>10)on ReHo chart analysis of depression group and normal control group.The ReHo value of the regions,such as the bilateral cerebellar foot 2 and the right fusiform gyrus before treatment,was increased,and the ReHo value of the right lower frontal gyrus was reduced(P<0.05,K>10).Compared with the healthy control group,left middle frontal gyrus,anterior cingulate gyrus,medial frontal gyrus,occipital gyrus,temporal gyrus and right medial cingulate gyrus,medial frontal gyrus,inferior frontal gyrus,middle frontal gyrus decreased ReHo,left cerebellum posterior lobe,fusiform gyrus,thalamus,occipital gyrus and right middle occipital gyrus,inferior parietal margin angular gyrus increased ReHo(P<0.05,K>10).Conclusions Difference in ReHo value of functional related brain regions in patients with depression can indirectly reflect the changes in the time synchronism of the neurons in the functional brain region,which is helpful for the evaluation of the treatment effect of depressive patients and the location detection of the abnormal active brain area.Part II The study of brain fMRI in task state of first-episode patients with mild and moderate depression before and after treatmentObjective To explore the functional state of the abnormal brain regions in first-episode patients with mild and moderate depression before and after treatment through the characteristics of cognitive bias of negative emotion information,which would provides a new basis of imaging for the evaluation of the treatment rate of depression.Methods 14 first-episode patients with mild and moderate depression[live up to DSM-Ⅴ diagnostic criteria for depression,Hamilton Depression Scale(HAMD-17)score 17～24 points]and 14 matched healthy volunteers were examed by rfMRI.The stimulus materials are randomly selected from the revised CAFPS to randomly select 60 neutral pictures and negative pictures..In this study,a total of 5 block and 60 trials were designed.The 8 patients underwent rfMRI scan after 6 weeks of drug treatment.The statistical analysis is completed by SPM8 software package.Results In the negative emotion expression stimulation,the left brain inferior temporal gyrus,right middle temporal gyrus and frontal middle gyrus in patients with depression increased compared with healthy controls(P<0.05,K>10).The activation of the brain area in the angular gyrus of the bilateral top and lower edge of the brain was enhanced after the treatment(P<0.05,K>10).Compared with healthy controls,activation of right occipital gyrus and left fusiform gyrus decreased,while right frontal medial gyrus,middle temporal gyrus,posterior cingulate gyrus and left inferior temporal gyrus,superior temporal gyrus and inferior inferior marginal gyrus increased(P<0.05,K>10).Conclusions After short-term antidepressant treatment,the brain areas associated with negative emotion in patients with depression are better than those in the previous part,however,there is still a certain degree of functional impairment,which may be related to the recurrence of depression.It is further confirmed that functional magnetic resonance imaging(fMRI)provides an objective imaging basis for clinical efficacy and prognosis evaluation.