Resting State Functional Magnetic Resonance Imaging Of First Episode Depression Patients Before And After Treatment

Objective:Depression is a common mental disorder, and its pathogeny is still unknown. New diagnostic methods and biomarkers are urgently needed for clinical diagnosis. In this study we attempt to investigate the before and after the treatment in MDD b yrs-fMRI.Method:We used rs-fMRI to measure functional changes in the brain of first-episode, treatment-naive MDD patients (n= 21) immediately(before and then following 12 weeks),and sex-, age-and education-matched healthy controls (HCs, n= 24) were subjected to resting state functional magnetic resonance imaging (rs-fMRI) and fractional amplitude of low-frequency fluctuations (fALFF) and Regional homogeneity (ReHo) were compared between the groups. All the data and ReHo, fALFF analyses were preprocessed with the Data Processing Assistant for Resting-State fMRI (DPARSF). All of the statistical analyses were performed using the REST software to explore the differences in ALFF and fALFF between migraine patients and HCs. Pearson correlation analysis was performed between regional fALFF and psychometric scores, ReHo and psychometric scores.Results:1. The total score of HAMD in the treatment group was lower than that before treatment (p<0.05).2. Compared to HCs, before treatment MDD subjects had increased fALFF in the bilateral cerebellar posterior lobe, right middle temporal gyrus, left anterior central gyrus (p<0.001), and reduced fALFF in the left anterior cingulate gyrus, left superior frontal gyrus, right occipital gyrus (p<0.001) which were similar to the differences observed between the HCs and before treatment MDD patients. Compared to after treatment MDD patients, MDD subjects showed significant increased fALFF in the left middle frontal gyrus (.p<0.001), and reduced fALFF values in the right middle temporal gyrus (p<0.001)3. Compared with HCs, before treatment MDD subjects had showed increased ReHo in the right superior temporal gyrus, right temporal pole (p<0.001) and decreased ReHo in the right middle frontal gyrus, left inferior parietal gyrus (p<0.001) Compared with HCs, after treatment MDD subjects had showed increased ReHo in the left temporal pole, bilateral occipital gyrus, left superior temporal gyrus, inferior temporal gyrus (p<0.001) and decreased ReHo in the right posterior lobe, right superior frontal gyrus (p<0.001). Compared to after treatment MDD patients, before treatment MDD subjects showed significant increased ReHo values in the left superior frontal gyrus (p<0.001)4. There were no significant associations between HADM scores and fALFF values, HADM scores and ReHo values in MDD group before the treatment compared with healthy control group of abnormal brain regions. (Both p>0.001).Conclusions:1. First-episode MDD patients have abnormal spontaneous activity in the specific change, these abnormal brain regions fALFF and ReHo value measurements may help in the detection and diagnosis of MDD, to our understanding of the pathogenesis of MDD provide new insights, thus providing early diagnosis of latent image index.2. Antidepressant in the treatment of brain function change, but compared with healthy controls, there are still some degrees of abnormal, fALFF and ReHo of resting state fMRI based on clinical more objective dynamic evaluation of antidepressant drugs could offers some references.