| Objective:To explore the value of preoperative FAR in the diagnosis of ovarian cancer and the clinical significance of the assessment of prognosis,provides reference for the clinical diagnosis and prognosis of OC.Methods:From November 2004 to December 2018,clinical records of 125 cases of patients with ovarian malignant tumor diagnosed by pathology in the affiliated hospital of Yanbian university were collected as the observation group,178 cases of ovarian benign tumor and 88 cases of healthy people as the control group,and the relationship between various indexes in preoperative serology in the three groups was compared and analyzed.The ROC curve was established to determine the optimal cut-off point of preoperative FAR in OC diagnosis.Based on this,it was divided into high value group and low value group.The relationship between FAR and the clinical pathological characteristics of OC patients was analyzed.Results:1.The inflammatory indicators(FAR included)in the ovarian cancer group were higher than those in the benign tumor group and the healthy group,and the indicators representing nutrition were lower than those in the benign tumor group and the healthy group,but the FAR levels in the benign tumor group were lower than those in the healthy group,with statistically significant differences.2.ROC curve results of FAR diagnosis OC:AUC is 0.719(P<0.001),95%CI is 0.664-0.774,Se is 0.600,Sp is 0.713,cutoff value of 0.0707,according to this to FAR points in the two groups(high value group>0.0707 and low value group ?0.0707).3.The level of FIB,leukocyte,platelet,neutrophil,PLR and NLR in the FAR high value group was higher than that in the low value group,while the level of albumin and PNI in the high value group was lower than that in the low value group,with statistically significant differences.4.FAR was positively correlated with PLR,leukocytes,platelets,neutrophils,and FIB(all P<0.01),and negatively correlated with lymphocytes(P<0.05)and albumin(P<0.01).5.Among OC patients,ascites associated with FAR decreased more frequently,but ascites associated with FAR increased more(1000ml)and the later FIGO stages were more common.In the high-value group,FAR presented a declining trend with the increase of disease severity(FIGO stage)(Ptrend=0.014),and the difference was statistically significant,but there was no statistical significance in age,differentiation degree,and histological type factors between the two groups.6.Among the OC patients,OS,5-year and 10-year survival time in the FAR low value group were significantly higher than those in the high value group(P<0.05),and the 5-year and 10-year survival rates were 69.8%and 65.1%,respectively.In the risk regression model,the single factor analysis of FAR high value,age,abdominal water content of 1000ml,degree of differentiation and FIGO stage were the influencing factors of OC.However,the multiple factor analysis of FAR was not the independent influencing factor of OC,while the ascites ?1000ml and low differentiation were independent risk factors affecting OC,and the medium differentiation and high differentiation were protective factors.Conclusion:1.The preoperative FAR value of patients with ovarian malignant tumor was significantly higher than that of patients with ovarian benign tumor and healthy people,and it had certain diagnostic value for ovarian malignant tumor.2.FAR has a certain clinical significance for the prognosis of ovarian cancer.High FAR is related to the short overall survival period of OC,but is not an independent factor.3.The higher the FAR value,the higher the indicators representing inflammation and the lower the indicators reflecting nutrition. |
PDF Full Text Request