| OBJECTIVE: Diabetic osteoporosis(DOP)is a systemic metabolic bone disease in patients with diabetes mellitus(DM)with bone loss,bone tissue changes and fracture manifestations,which is affected by many factors.A large number of studies have shown that abnormal bone nutrition status caused by diabetes increases the probability of osteoporosis in patients,which is a risk factor for osteoporotic fractures in patients.According to clinical statistics,in patients with diabetes,the probability of osteoporosis is more than 50%,especially in postmenopausal women,which seriously affects the quality of life of diabetic patients.To analyze the risk factors affecting osteoporosis in diabetic patients,and provide reference for the prevention and treatment of diabetic osteoporosis.METHODS: A total of 1080 patients with type 2 diabetes admitted to the endocrinology department of the Dalian Medical Affiliated Second Hospital from December 2016 to November 1818(according to the 1999 WHO standard for diagnosis of type 2 diabetes)were enrolled.The clinical data of the patients enrolled were complete,aged 30-75 years.According to the patient’s bone mineral density,they were divided into normal group,bone density reduction group and osteoporosis group.There were 540 patients with normal bone density,including 235 males and 305 females,aged 34-67 years old.The density decreased by 320 cases,including 93 males and 227 females,aged 35-69 years,and 220 patients with osteoporosis,including 43 males and 177 females,aged 45-72 years.Collect basic patient information: smoking,alcohol abuse,age,gender,place of origin,temporary residence,race,hip circumference,waist circumference,body weight,lifestyle,exercise habits,and eating habits.Auxiliary examination: fasting blood glucose,postprandial 2h blood glucose,glycosylated hemoglobin,low density lipoprotein cholesterol,high density lipoprotein cholesterol,very low density lipoprotein cholesterol,fasting insulin level,estrogen level,fasting C peptide level,insulin sensitivity index Bone density,vitamin D3,procalcitonin,insulin-like growth factor 1(IGF-1),TSH,insulin levels,and bone strength.Treatment compared with diabetic patients with osteoporosis,bone mineral density and bone mineral density normal correlation indicators,analysis of the factors affecting the occurrence of diabetes and osteoporosis.RESULTS: There were significant differences in age,sex ratio,duration of diabetes,and body mass index among the three groups(P<0.05).The three groups were associated with waist-to-hip ratio(WHR),systolic blood pressure(SBP),and diastolic blood pressure(DBP).There was no significant difference in the proportion of postmenopausal women(PMW)(P>0.05).There were significant differences in HbAlc,HDL-C,PCT,vitamin D3,IGF-1,PTH and insulin among the three groups(P<0.05).There were no significant differences in FPB,2HPG,serum phosphorus,serum calcium,TC,TG,TSH,and LDL(P>0.05).Multivariate logistic analysis showed that women,advanced age,long diabetes,low BMI,low HDL-C,low vitamin D3,low insulin levels,low IGF-1,high PTH,high PCT,and high HbAlc were independent risk factors for osteoporosis in diabetic patients(P<0.05).Conclusion: The risk factors for osteoporosis in type 2 diabetes include female,advanced age,long course of disease,low high density lipoprotein cholesterol,low vitamin D3,low insulin level,low insulin-like growth factor 1,high parathyroid hormone,Low body mass index,high procalcitonin,and hyperglycated hemoglobin are key to reducing the incidence of diabetes and osteoporosis. |
