Study On The Composition Rules Of Prescription Of Chinese Herbal Compound In Treating Insomnia Based On Clinical Evidence

Objective: clinical control study literatures of TCM treatment for insomnia of high grade argument based on the two data mining on document retrieval in the selection of drugs as the starting point,analysis of statistical data of the TCM inheritance system,aims to explore the treatment of insomnia and the prescription drug laws,further summarized the etiology and pathogenesis of insomnia,search for the corresponding treatment and prescription.It is expected to provide a reliable basis for clinical research and treatment.Method: first,formulate the inclusion criteria,retrieval China Journal Full-text Database(CNKI),VIP database(VIP),Wanfang Data Resource three Chinese database,in strict accordance with the inclusion criteria for screening clinical research literature retrieval.Then,from the retrieval literature,one by one to extract the data,establish a database to save the data,two people from the corresponding modules data entry to the TCM inheritance system analysis,improved mutual information method,complex system entropy clustering rules and unsupervised entropy level clustering of data,obtained results,the frequency of the drug the commonly used drugs,drug distribution,four five kinds of distribution,channel distribution,frequency of drug dosage,the new analysis results,and to visual network graph display.Finally,the statistical results are summarized and analyzed,and the prescription rules of drugs and prescriptions are explored,and the insomnia pathogenesis is further summarized.Results: the results of prescription retrieval: 444 articles were selected from 2608 literatures,and 452 prescriptions were collected.Results: the frequency of the drug use frequency in the top ten for drugs(with common dosage analysis): Suanzaoren(30g,15 g,20g),Poria(15g,10 g,12g),Caulis Polygoni Multiflori(30g,15 g,20g),Angelica(10g,15 g,12g),Yuanzhi(10g,15 g,12g),licorice(6G,5g,10g),bupleurum,Radix Paeoniae Alba(10g,12 g,15g,),Baishao(15g,12 g,20g),Chuanxiong(10g,15 g,9g),Poria(15g,10 g,20g).Results: four drug distribution in flat,warm,cold,flat of drugs in the highest proportion,accounting for 34%,Wen medicine,cold medicine is similar,accounted for 32%,29%;medicine and medicine use low frequency,accounted for only 2% of the following.Results: the distribution of five drugs to sweet,bitter,pungent,sweet medicine with high frequency,the proportion of 38%,25% and 20% respectively;acid,salty less used in treatment of insomnia,astringency seldom used.Results: the distribution of drug meridian viscera: heart,liver,spleen,kidney,lung,the proportion is as follows: 27%,24%,19%,15%,14%;six: stomach,gall bladder,large intestine,small intestine meridian,pericardium meridian,bladder meridian,sanjiao meridian,the proportion is as follows: 39%,32%,14%,4%,3.5%,3.3%,2.6%.Results of commonly used drug combinations were: sour jujube kernel,Caulis Polygoni Multiflori,sour jujube kernel,Poria cocos,sour jujube kernel,angelica,sour jujube kernel,Polygala tenuifolia,sour jujube kernel,licorice,keel oyster,Poria,Polygala tenuifolia,jujube kernel bupleurum,bupleurum,Paeonia lactiflora,angelica and Polygala tenuifolia.The new analysis results: No.0: Zhuru,Coptis chinensis,Fructus aurantii Immaturus,gelatin,egg yellow.1 new party: wood,Codonopsis,jujube,ginger,cinnamon branch.New No.2: keel,oyster,uncaria,tangerine.New No.3: Radix Paeoniae Alba,gelatin,egg yellow,bupleurum,Radix curcumae.New No.4: ophiopogon root,figwort root,asparagus,red ochre,Kawa Ko.New No.5: the Divine Comedy,Atractylodes rhizome,Rhizoma Cyperi,Tribulus terrestris,Albizia julibrissin,shijueming.6 new party: longan,astragalus,Atractylodes,wood and angelica.New No.7: tuckahoe,citrus,Poria,bamboo shavings,pinellia,dried orange peel.8 New Party: Radix rehmanniae,licorice,Cornus officinalis,yam,Alisma orientalis and peony skin.Conclusion: the treatment of insomnia is treated with the method of regulating mentality.It is treated with the syndrome of activating blood,nourishing Yin,dispersing the liver and eliminating phlegm.The viscera are caused by insomnia,liver and heart as the main cause,treatment when treatment from heart,treatment from liver.Suanzaoren-Radix Polygoni multiflorum,keel-oysters,Suanzaoren-Angelica,pinellia pericarp-Dried tangerine peel radix bupleuri-radices paeoniae alba are commonly used in the treatment of insomnia.9 new prescriptions for insomnia were summed up for reference and verification in clinical study.