Study On Protective Effect Of Omeprazole On Upper Gastrointestinal Mucosa In CHPS

Objective Congenital hypertrophic pyloric stenosis(CHPS)is an incomplete obstructive disease of the upper digestive tract due to pyloric hypertrophy and pyloric stenosis.Pyloric stenosis and repeated vomiting often lead to lesions such as congestion,edema,and erosion of the gastric mucosa,which have adverse effects on endoscopic surgery and postoperative recovery.Therefore,to reduce and prevent gastric mucosal hyperemia,erosion and edema,and promote postoperative pyloric function recovery in children with CHPS is a hot research topic of endoscopic therapy.In this study,we retrospectively analyzed the effect of proton pump inhibitor omeprazole on gastric mucosal lesions in children with CHPS.The aim was to provide a theoretical basis for endoscopic treatment of CHPS.Methods A total of 76 children with congenital hypertrophic pyloric stenosis diagnosed at the Department of Neonatology of the First People's Hospital of Guangzhou from July2006 to June 2017 were selected for recurrent vomiting.According to the use of omeprazole is divided into A,B,C,D four groups.The untreated patients were control group A and 17 patients in total;those with drug treatment less than 5 days were in group B and 22 patients;those in drug treatment group 5-10 days were in group C and 26patients;those in drug treatment more than 10 days were group D,11 example.In groups B,C and D,omeprazole was used for intravenous infusion and the dose was 0.8-1.0 mg/kg.d once daily.The number of cases of hyperemia,edema,and erosion of gastric mucosa and esophageal mucosa was observed under ultramicroscopic gastroscopy.The relationship between the incidence of gastric mucosal lesions and the time of treatment with omeprazole was compared.SPSS 20.0 software was used to analyze the data.Measured data were expressed as mean ± standard deviation.Chi-square test was used to compare the data of each group.P value less than 0.05 was considered statistically significant.Results The erosion rates in group A,group B,group C,and group D were 36.24%,31.29%,12.73%,and 14.00%,respectively.A group was significantly higher than the other groups(F=0.03,p=0.000).The B group was significantly higher than the C group(p=0.000).The incidence of the C group was significantly lower than the A and B groups(p=0.000).There was no statistical difference compared with D group(p=0.376).The incidence of edema in group A,group B,group C,and group D was 59.03%,45.57%,28.09%,and 28.38%,respectively.A group was significantly higher than other groups(F=0.135,p=0.000).Group B was significantly higher than group C(p=0.000).The incidence of group C and A and B were significantly lower(p=0.000).There was no statistical difference compared with D group(p=0.706).The incidence of hyperemia in group A,group B,group C and group D was 55.52%,50.65,38.73,and 29.98,respectively.There was no significant difference in the average incidence of hyperemia between groups(F=0.745,p=0.670).Conclusions Omeprazole can significantly reduce the incidence of digestive mucosal erosion,edema and other complications in children with CHPS,and 5-10 days is a good treatment time.