Clinical Study On The Relationship Between The Level Of Plasma Lipoprotein Associated Phospholipase A2 And Coronary Artery Lesions

[Background] Inflammatory response is an important feature of coronary heart disease and is closely related to the progress and stability of plaque.The study showed that the inflammatory markers such as interleukin,tumor necrosis factor and C-reactive protein had significant correlation with the occurrence,development and prognosis of coronary heart disease.Plasma lipoprotein associated phospholipase A2 is a new marker of inflammation associated with coronary heart disease and may be directly involved in the coronary heart disease process.In this study,the correlation between the levels of lipoprotein associated phospholipase A2 and homocysteine and coronary artery lesions was investigated by testing the levels of lipoprotein associated phospholipase A 2 and homocysteine in each group,combining with the history and clinical examination of the patients.[Object] 1?To study the relationship between the level of plasma lipoprotein associated phospholipase A2 and the range of coronary lesions,and to detect the relationship between homocysteine level and coronary heart disease.2?Comparison of A2 levels of plasma lipoprotein associated phospholipase among patients with different coronary lesions [Method] The 227 patients admitted to the Second People's Hospital of Guangzhou Medical University from June to December 2015 were selected to determine the level of lipoproteinase A2,homocysteine,and blood lipid levels in plasma specimens of the patients.,while coronary angiography,Divided into experimental groups(when the lesion lumen stenosis was 50 % coronary atherosclerosis;The lesion ? 50 % stenosis was a positive standard)and the control group(coronary artery without stenosis),Finally,the relationship between risk factors such as age,sex,history of hypertension,history of diabetes,history of hyperlipidemia,history of smoking,plasma lipoproteinase A 2,homocysteine level and coronary heart disease were analyzed.All the data in this study were analyzed by SPSS 21.0 software.The quantitative data is described by X ± S and the qualitative data is represented by N(%).The components are compared with F inspection and card inspection;The comparison between the two groups uses the LSD method and reports the LSD-t value.The method of Logitic regression analysis is used for multifactor analysis.[Results].Coronal artery angiography confirmed that there were no abnormalities in 73 coronary arteries,154 abnormal coronary coronary artery patients,35 coronary atherosclerosis,49 single lesions,28 double lesions,and 42 three lesions.The comparison between the two groups uses the LSD method and reports the LSD-t value.The average level of lipopoprotein associated phospholipase A2 in the coronary abnormal group was 309.60 ± 112.07 ug/L,which was significantly higher than that of 197.30 ± 75.43 ug/L without coronary abnormalities,and there was a significant difference between the two groups,P<0.001.Patients with coronary abnormalities were divided into four different subgroups.The levels of lipoprotein associated phospholipase A 2 in the coronal atherosclerosis group,single-,double-and three-lesion groups were: 291.49 ± 101.27 ug/L,293.84 ± 113.47 ug/L,295.18 ± 132.47 ug/L,352.71 ± 95.26 ugL/L,The results showed that the lipid-related phospholipase A2 water in each subgroup was higher than that in the control group,and the difference was statistically significant(P<0.05).The LP-PLA2 levels were higher in the three coronary lesion groups than in the coronary atherosclerosis group,single and double lesion groups,respectively.and the difference was statistically significant(P<0.05).The LP-PLA2 level was closely related to the range of coronary lesions,and the increase of the three lesions was most significant.There was no significant correlation between Hcy level and coronary lesion.[Conclusion] 1.Increased level of lipoprotein associated phospholipase A 2 in patients with positive coronary artery lesions 2.The increased level of plasma lipoprotein associated phospholipase A2 was closely related to the vascular range of the lesions,and the increase was most significant in the three patients.