| Objective: The purpose of this study was to explore the serum Lp-PLA2 expressionlevel before,48 hours after and 1 year after operation in PCI(percutaneous coronary intervention)patients,and then to investigate the relationship between serum Lp-PLA2 level and coronary stenosis degree,as well as in-stent restenosis.Methods:Collect 83 patients(58 male and 25 female patients,average age =(58.57±6.01)years.)with coronary heart disease(including acute myocardial infarction)hospitalized in the second hospital of Hebei Medical University between January,2016 and December,2017 were selected by retrospective clinical study.All patients underwent coronary angiography(CAG)and via PCI,and the coronary angiography was reviewed 1 year later.1.The age,sex,height,weight,HPI(history of present illness),past medical history,personal history,family history,and BMI(Body mass index)were recorded.2.According to the results of the first coronary angiography,the severity of coronary stenosis was evaluated by using syntax scoring system,and the patients were divided into three groups: Mild stenosis Group(0-22),Moderate stenosis Group(23-32),and severe stenosis Group(≥33).According to the results of the second coronary angiography,the patients were divided into two groups: In-stent restenosis Group(ISR)and Non-in-stent restenosis Group(NISR).3.The fasting blood samples were collected at preoperative,48 hours and1 year after operation,and the serum Lp-PLA2 level was measured by enzyme-linked immunosorbent assay(ELISA).Results:1.Comparison of the basic situation.(1)There was no statistically significant difference in age,sex ratio,BMI,blood pressure level,smoking history,drinking history and family history of coronary heart disease(P >0.05)among groups by SYNTAX score(P >0.05),and there was no statistically significant difference in laboratory examination Indexes(P >0.05).(2)There was no statistically significant difference between the Restenosis group and the stent-free restenosis Group in age,sex ratio,BMI,blood pressure level,smoking history,drinking history and family history of coronary heart disease(P >0.05),while the difference of fasting blood glucose and low-density lipoprotein were statistically significant in laboratory indexes(P <0.05).2.Comparison of the serum LP-PLA2 levels between before and after the operation for 48 hours.The serum Lp-PLA2 level of 48 hours after operation was significantly higher than the preoperative level of serum Lp-PLA2,(P <0.05).And it was also significantly difference among the different coronary lesions(P <0.05).3.Comparison and correlation analysis of preoperative Lp-PLA2 level between patients with different severity of coronary lesions.(1)The preoperative serum Lp-PLA2 level was significantly higher in the Severe lesion group(313.00±19.06)than the moderate lesion group(276.46±12.41,)and mild lesion group(240.05±9.05),the preoperative serum Lp-PLA2 levels of each group were statistically significant(f=191.941,P<0.01).(2)The preoperative serum Lp-PLA2 level was positively correlated with the severity of coronary lesions(SYNTAX score)(r=0.982,P<0.01),suggesting that the higher the serum Lp-PLA2 level,the coronary lesions could be more serious.4.Comparison of serum Lp-PLA2 levels between the groups with or without in-stent restenosis 1 year after operationOne year after surgery,19.27%(16/83)of the patients showed stentrestenosis,in which the level of serum Lp-PLA2 level(300.44±30.44)in patients with restenosis was significantly higher than that in patients with no restenosis(280.26±27.71)(t=2.854,P =0.005).Conclusions:The level of serum Lp-PLA2 is positively correlated with the severity of coronary lesions,which means that the higher the level of serum Lp-PLA2 may lead to the severity of coronary lesions.At the same time,the level of serum Lp-PLA2 in patients with in-stent restenosis is significantly higher than that in patients without in-stent restenosis.It is suggested that the higher level of serum Lp-PLA2,the greater the risk of in-stent restenosis. |
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